Chromosomes fold into distinct domains that regulate transcription, replication and repair. In addition to well-characterized topologically associating domains (TADs) and compartments, the diversity of heterochromatin domains remains poorly defined at the sequence level. Here, using single-molecule tracing of nascent h...
Dania Camila Pulido Barrera, J. E. You, Angelo L. Angonezi et al.· Nature Structural & Molecula...· 0 citations
CropStabDB: a protein stability resource and Engineering Atlas of orthologue-supported substitutions for 30 plant proteomes Version 2.1.1. CropStabDB is a protein stability resource for 30 plant species - 29 crops and Arabidopsis thaliana, spanning 12 families and 1,425,716 proteins. Each protein carries a CropStab sco...
Chronic kidney disease (CKD) is a common acquired disorder in older cats and is associated with tubulointerstitial fibrosis, chronic inflammation, hypoxia, oxidative stress, and extracellular matrix (ECM) remodeling. Matrix metalloproteinase-7 (MMP7), a tubular epithelial-derived endopeptidase, has been implicated in r...
Sinan Vıcıl, Tuğrul Kırkulak· Journal of Advances in VetBi...· 0 citations
Background: Certain antiretroviral drugs, including efavirenz, have been associated with mitochondrial and oxidative effects in hepatic cells, but quantitative translation from nominal in vitro concentrations to an in vivo effect-site concentration remains uncertain. Methods: A hypothesis-generating physiologically bas...
Bárbara Costa, M. Gouveia, Nuno Vale· Pharmaceutics· 0 citations
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How ribosomes pace translation to assist nascent protein folding remains an open question in molecular biology. While synonymous codon selection is widely hypothesized to regulate elongation rates to facilitate domain organization, distinguishing genuine translational kinetics from baseline amino acid preferences has p...
Muhammad Saad Ul Hassan, Ishrat Jabeen, Yusra Sajid Kiani· bioRxiv (Cold Spring Harbor...· 0 citations
Reliability boundaries of protein language-model zero-shot variant scores: unified-score author-review research release Version: 2026.10.02-author-review. Scientific submission HOLD. Publication of this research artifact does not constitute journal submission, acceptance or independent scientific clearance. Scientific...
Zeyu Fu· Zenodo (CERN European Organi...· 0 citations
isoform-dominance 2.4.1 A maintenance release from a post-release audit of 2.4.0. Several fixes change an answer, because the code now does what the documentation already said or because 2.4.0's answer was wrong; they are listed first. The rest stop a traceback or a misleading message, or fix a record, a script or the...
S.I. Kim· Zenodo (CERN European Organi...· 0 citations
Oncogenic p53 mutant proteins not only promote cancer cell proliferation but also evade immune destruction for tumor progression. Besides hijacking immune checkpoints, p53 mutants in cancer cells may deactivate anticancer immune cells for evasion. Herein, we report that p53 R273H mutation in human breast cancer cells d...
M. N. Amin, M. Mostaq, S. Jois et al.· Current Issues in Molecular...· 0 citations
Native chickpea protein isolate (CPI) exhibits unsatisfactory solubility and dispersibility, restricting its interfacial performance and emulsion-stabilizing capacity. Herein, CPI gels were subjected to combined high-pressure homogenization and ultrasonication pretreatment to fabricate CPI microgel particles (CPIMPs),...
Xiang-Xiang He, Xin-Yi Song, Li-Ping Ma et al.· Foods· 0 citations
Release v1.4 (2 October 2026) Adds the analyses cited in the Virology submission (Sections 2.2, 2.6, 2.8, 3.5 to 3.8). Earlier releases are unchanged. Every new script uses the project seed 20260817, prints its progress, takes its external inputs from the repository folder, and writes to results/. All six scripts were...
Abdelmuhsen Abusneina· Zenodo (CERN European Organi...· 0 citations
Background/Objectives: Prospective studies have reported associations between systemic inflammatory biomarkers and colorectal cancer (CRC) risk, but whether these reflect a causal role of inflammation or responses to preclinical disease remains uncertain. Methods: Using data from 383,850 UK Biobank participants (aged 4...
F. Safizadeh, T. Gwenzi, Marko Mandic et al.· Cancers· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
