AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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2,141 papers
It is demonstrated that conformationally distinct tau polymorphs associate with disease-specific interaction networks across Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies, providing molecular insight into tauopathy heterogeneity.
These highly powered, sedation-contextualized RI provide a definitive, species-specific diagnostic framework that will significantly enhance veterinary care, colony management, and the interpretation of translational research utilizing A. nancymaae.
Differential serum peptide expression in AR patients treated with BJK remedy compared to loratadine compared to loratadine is investigated using MALDI-TOF MS and LC-MS/MS to elucidate the mechanisms of BJK remedy and loratadine in treatment, supporting the further development of targeted therapies and biomarkers.
MCTH (Monte Carlo Tree Hallucination), an inference-only framework that casts all-atom sequence-structure co-design as uncertainty-aware planning over hallucinated states from pretrained folding and inverse-folding models, with optional biophysical control within the same decision loop is introduced.
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HRBD demonstrated potent and broad-spectrum inhibition against Pangolin-CoV, SARS-CoV, SARS-CoV, SARS-CoV-2, and its variants, lowering the half-maximal inhibitory concentration (IC50) by approximately 1000-fold compared to the monomeric RBD.
Results demonstrated that the chimeric vaccine provides preliminary protection against a local B2 UPEC isolate, and modulating gut microbiota via faecal transplantation markedly enhances the immunogenicity and protective efficacy of vaccination, suggesting its adjuvanticity.
In situ atomic force microscopy is used to reveal the two-dimensional crystallization dynamics of streptavidin on muscovite mica with single-molecule resolution, establishing a paradigm of domain coarsening in biomolecular epitaxy, providing a solid foundation for the rational design of functional bio-nano interfaces.
ProteinReasoner is developed, a multimodal generative protein foundation model that sequentially connects amino acid sequence, evolutionary constraints and three-dimensional structure within a shared autoregressive architecture and suggests a general route towards reasoning across interdependent representations in othe...
Porous silicon (PSi) biosensors offer significant potential for point-of-care diagnostics, yet their analytical performance is constrained by slow analyte diffusion into the porous matrix. To address this issue, we developed a lab-on-a-chip (LOC) device that combines a PSi immunosensor with a surface acoustic wave (SAW...
This strategy provides a rapid, selective, and scalable way to introduce aromatic PTMs, producing homogeneous protein libraries essential for mechanistic studies, biomarker development, and exploring the therapeutic potential of targeting aSyn-phosphorylation for PD and related disorders.
Results identify Cryaa as a critical regulator of ER stress and demonstrate that its reduction promotes UPR activation and subsequent photoreceptor apoptosis in the rd9 model, revealing a key role for Cryaa in XLRP pathology and may provide a novel therapeutic perspective for this disease.
ABSTRACT Microplastics (MPs) accumulation in ecosystem and human organs poses urgent environmental and health risks, yet few enzymes efficiently degrade polyethylene terephthalate (PET) under physiological conditions. We leveraged deep learning to mine unexplored sequence space across 246 million proteins, discovering...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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