It is shown that DBD alone produces dose-dependent repression of DUX4-FL transcriptional activity in HEK293T cells, while a constitutively expressed DBD-KRAB fusion produces significantly greater repression than DBD alone, with a similar trend observed in C2C12 myoblasts.
H. Hoffmann, A. Finkelstein, Amanuel W. Geremew et al.· bioRxiv· 0 citations
A glycan-dependent chaperone network is defined, finely tuned by a combination of low-micromolar interactions between the constituents, that ensures efficient MHC-I maturation and illustrates fundamental principles of ER protein quality control.
Tim J. Heinke, Amin Fahim, Niko Popovic et al.· EMBO Journal· 0 citations
A previously unrecognized mechanism regulating RNase activity in a dicot PM RALPH effector is revealed and new insights are provided into the functional diversification of RALPHs and their adaptation to obligate biotrophy.
Biochemical evaluation of triazinone 3 revealed significant reductions in acetylcholinesterase activity and in total protein, carbohydrate, and lipid contents compared with untreated larvae, indicating that larval mortality was accompanied by cholinergic disturbance and depletion of metabolic reserves.
E. El-Helw, Mahmoud Kamal, Eslam M. Hosni et al.· Bioorganic chemistry (Print)· 0 citations
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A testable positive-feedback perspective in which thyrocyte ERS injury and immune effector amplification may mutually reinforce one another is proposed, in which thyrocyte ERS injury and immune effector amplification may mutually reinforce one another.
X. Si, Zhi-Xun Guo, Ge-Na Jiao et al.· Frontiers in Immunology· 0 citations
A DDP-doped black phosphorus (BP) nanomedicine protected by polydopamine coating that synergistically delivered DDP and piezoelectric BP to precisely disrupt resistance homeostasis and thereby reverse DDP resistance is established.
Yijie Fan, Jingning Zhang, Cong Liu et al.· Advances in Materials· 0 citations
The most potent strain, Bacillus paralicheniformis UB08 (TISTR 10842), displayed an extraordinary nominal Pb tolerance, with a minimum bactericidal concentration exceeding 9,000 ppm, and alginate bead encapsulation enables rapid and complete Pb removal, offering a promising solution for heavy metal treatment based on p...
Kaninnut Sangkhum, T. Panich-pat, P. Nimnoi et al.· PeerJ· 0 citations
The proposed multi-epitope vaccine shows promising immunological and structural properties, supporting its potential against S. typhimurium, pending experimental validation.
Mohammed Naveez Valathoor, A. P. Rajan· Scientific Reports· 0 citations
Pockets from a protein language model at locations where geometry finds no concavity improves single-structure recovery by 8.5% (95% CI +4.0 to +13.6) on test-fold data, and lets a five-conformer ensemble match a twenty-conformer one at a third of the wall clock.
Data reveal for the first time that CIGB-300 treatment is able to induce extracellular HMGB-1 release in vitro and in vivo which could be indicative of ICD induction in some kinds of tumors; furthermore, the induction of extracellular HMGB-1 alarmin as a putative CIGB-300 response biomarker merits further investigation...
Daylen Aguilar-Noriega, Ying Yi, Jamilet Miranda et al.· Kinases and Phosphatases· 0 citations
An evolved hierarchy of paralog-specific JDP couplings that dynamically rewires the Hsp70 network from active repair to protection during stress is revealed, revealing an evolved hierarchy of paralog-specific JDP couplings that dynamically rewires the Hsp70 network from active repair to protection during stress.
Roni Suhler, Lars J. W. van Beurden, Merav D. Shmueli et al.· Proceedings of the National...· 1 citation
It is demonstrated that conformationally distinct tau polymorphs associate with disease-specific interaction networks across Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies, providing molecular insight into tauopathy heterogeneity.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
