Type 2 diabetes mellitus (T2DM) remains a global health crisis, with nearly 589 million adults currently affected and projections pointing toward 853 million by 2050. Despite an expanding pharmacological armamentarium, a significant proportion of patients fail to achieve adequate glycaemic control, and the limitations...
A. Dadhich, Vikas Sharma, Shivika Sharma et al.· Pharmaceutics· 0 citations
PRMT5 and RBM39 inhibition regulate DNA repair and metabolic pathways. A, Workflow of the RNA-seq approach: PSN1 cells were treated with DMSO as the vehicle control, 4 nmol/L JNJ-64619178, 200 nmol/L indisulam, or the combination of 4 nmol/L JNJ-64619178 and 200 nmol/L indisulam for 48 hours, mRNA was isolated, and mRN...
Valentina Spielmann, Jonas Buchloh, Selen Selcen et al.· 0 citations
A collaboration between researchers in the United States, the United Kingdom and Hungary has mutated the amino acid sequence of the AppA BLUF domain, a blue-light photoreceptor, and succeeded in capturing the proton-coupled electron transfer (PCET) radical intermediates that had never been observed in this protein. By...
inquantio· Zenodo (CERN European Organi...· 0 citations
Cold-start drug–target affinity (DTA) prediction requires evaluation on genuinely unseen chemical and protein entities. We considered QVGAT-DPI (Quantum Variational Graph Attention Network for Drug–Protein Interaction) as a residual hybrid model combining full molecular graphs, permutation-invariant Breaking of Retro-s...
TNG961 induces potent, selective CRBN-dependent degradation of HBS1L. A, Endogenous HBS1L degradation and PELO destabilization measured by Western blot after 24 hours of treatment with TNG961 in the indicated cell lines. The top dose was 10 µmol/L, tested as a 9-point, 3-fold dilution series. Representative images are...
Hilary E. Nicholson, Douglas A. Whittington, Frank J. Bruzzese et al.· 0 citations
Abstract This sub-paper, "Fractal Compact Manifold Theory Core Mechanics" serves as a concise, standalone distillation of FCMT's foundational elements, emphasizing the atemporal symmetry breaking, field emergence, Lagrangian formulation, projection operator, and foliation map. By focusing solely on these core mechanics...
Zachary Hosack· Zenodo (CERN European Organi...· 0 citations
Many biological processes rely on mechanical forces, with protein molecules acting as key mediators. Understanding how proteins respond to mechanical stress is essential for conditions including cardiomyopathy and muscular dystrophy. Natural proteins such as dystrophin and utrophin are composed of heterogeneous folding...
Cailong Hua, Yiyuan Zhang, Vinitendra Singh et al.· bioRxiv (Cold Spring Harbor...· 0 citations
Abstract Saccharomyces cerevisiae yeast is a widely used recombinant protein production host. Recombinant protein expression requires adaptation of the host cell proteome to accommodate the increased biosynthetic and folding demands. However, this underlying proteomic changes remain poorly understood. In this study, we...
Ryan Wong, Sahil Chandhok, Elizabeth Hui et al.· Applied Microbiology and Bio...· 0 citations
This model enables analysis of tumor-endothelial-stromal interactions in a pancreas-derived dECM environment and supported PDAC spheroid formation and the CD44-associated endothelial phenotype.
Han-Rong Li, Yi-Zhou Zhang, Chu-Han Ma et al.· Translational Research: The...· 0 citations
Chronic Myeloid Leukemia (CML) is a well-defined hematological malignancy driven principally by the BCR::ABL1 fusion oncogene and aberrant tyrosine kinase signaling. Computational methods to predict leukemia suffer from the limitation of using single-modality data or black-box models, which cannot adequately incorporat...
Atiq Ur Rehman, Ali Sayyed, Muhammad Ismail Mohmand et al.· Scientific Reports· 0 citations
This repository accompanies a computational analysis decomposing protein variant fitness into folding-stability and function components across 151 deep mutational scanning (DMS) assays from ProteinGym. For each assay, the agreement of every predictor with measured fitness was quantified, structure- and sequence-based s...
During initial prion infection, PrPSc drives mitochondrial dysfunction in a manner that is both strain dependent and independent of PrPC expression, while persistent prion infection increases mitochondrial sensitivity to cellular stress.
Daniel Shoup, L. Varner, B. Race et al.· Journal of Cell Science· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
