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2,039 papers
Overview A prospectively frozen benchmark suite for leakage-safe multi-omic integration. It tests predictive performance, modality utility, model-capacity effects, missingness handling, null behavior, exploratory external transport, failure handling, and compute cost without making claims of clinical utility or causal...
This research investigates the application of non-linear constraint optimization to biological systems, specifically focusing on optimization of gene expression and protein folding. Traditional optimization methods often struggle with the inherent complexity and dynamic nature of biological systems, necessitating novel...
Design principles that produces a robust and efficient heat shock response are revealed, including regimes of synergy as well as trade-offs between speed and efficiency, with wild-type parameters lying near the optimal region.
Uremic conditions are common in end-stage kidney disease (ESKD) patients. Accelerated vascular diseases in uremic patients lead to heart failure, stroke, and hypertension. To investigate the effects of uremia on porcine arterial smooth muscle cells (aSMCs), bulk RNA sequencing was used to identify uremia-induced altera...
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Temporal Wave Function Collapse Dynamics explores the theoretical underpinnings of the collapse of temporal wave functions – fundamental units of information within complex systems such as neural networks and protein folding – as a dynamic process. This paper posits that collapse isn't a discrete event but rather a con...
Molecular dynamics (MD) simulations are a fundamental tool in materials science, biology, and pharmaceutical research, offering insights into molecular behavior and dynamics. However, traditional MD simulations often suffer from limitations in accuracy and efficiency, particularly when dealing with complex, dynamic env...
Colorectal cancer (CRC) is a widespread health issue that attains high mortality. The adaptor protein SH3BP2 amplification results in metabolic changes, oxidative stress, NK cell activity, and inflammation. The NK cells are capable of destroying tumor cells without prior activation, help prevent metastasis, and have pr...
Researchers at Zhejiang University in China and Imperial College London in the UK built standalone tunnelling electrodes with an average gap of 1.6 nm at the tip of a nanopipette, and used them to identify single nucleotides and proteins electrically. By combining the probes with dielectrophoretic (DEP) trapping, which...
Researchers at Zhejiang University in China and Imperial College London in the UK built standalone tunnelling electrodes with an average gap of 1.6 nm at the tip of a nanopipette, and used them to identify single nucleotides and proteins electrically. By combining the probes with dielectrophoretic (DEP) trapping, which...
Derived data, run outputs and figure source data supporting the article "Joint optimisation of amino acid and coding sequence for de novo designed proteins". Includes the inverse-folding marginals for all 862 backbones and the full 230,992-row double-mutant additivity table.
Alfalfa biomass contains significant carbohydrate fractions underutilized in animal feed. This research optimized the enzymatic hydrolysis of Alfalfa biomass and evaluated single-cell protein (SCP) production using Candida utilis and Komagataella pastoris . Hydrolysis kinetics in this study showed biphasic sugar releas...
Glucoamylases are highly demanded by the industry for starch saccharification, which necessitates an increase in enzyme activity. To improve the activity of Aspergillus awamori VKPM F-1262 glucoamylase N181Q (AGAM), amino acid substitutions were made in the region of substrate binding. In the case of the variant D237G,...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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