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2,039 papers
This study optimized CHI–C/Geln bilayer patches for laparoscopic surgical application by controlling patch thickness through compression and found that these flexible adhesive patches could serve as topical hemostats that function effectively in laparoscopic surgery.
Decades of clinical trials targeting amyloid-beta plaques and tau tangles have yielded minimal therapeutic reversal in Alzheimer’s disease. Recent structural biology demonstrates that by the time macroscopic protein aggregates appear, the neuron’s fundamental information-processing highway—the microtubule lattice—has a...
Adseverin is a Ca2+-dependent, actin severing protein that promotes fusion of osteoclast precursors in osteoclast formation. Currently it is not understood how actin severing activity is regulated in osteoclastogenesis. Mass spectrometry of adseverin immunoprecipitates from osteoclasts showed that adseverin associated...
This paper investigates the algorithmic complexity of parallel simulations of complex systems, aiming to develop a novel algorithm that significantly reduces computational costs while maintaining accuracy. Complex systems, such as protein folding and climate modeling, demand substantial computational resources. Existin...
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This analysis identified a conserved newly formed differentiating (NFOL)/differentiating → lipid remodeling → Stress/ISR-reactive architecture, with a pronounced expansion of the Stress/ISR-reactive compartment and altered transition-associated pathway enrichment in high ADNC WM.
Simple Summary Bacillus thuringiensis Vip3 proteins are useful in biological control because of their specificity and low cross-resistance with Cry proteins. Therefore, it is important to reveal the insecticidal activities of these proteins by enhancing their efficacy. In this study, we aimed to investigate the insecti...
The results highlight the potential of virus-like particles (VLPs) as model systems for elucidating and engineering the self-assembly of hierarchical biomaterials, opening new avenues for the development of sustainable, tunable protein-based materials for advanced applications.
Temporal Topology Optimization (TTO) presents a novel approach to biological system optimization, moving beyond static parameterization to model the dynamic evolution of topological states. This paper introduces a system leveraging network theory and evolutionary dynamics to predict emergent behaviors within biological...
The findings provide a quantitative pharmacokinetic basis for the NO-mediated pharmacodynamic effects observed with both compounds and support the role of CIT as an effective oral precursor of ARG.
This paper introduces a novel self-adaptive optimization algorithm designed for modeling biological molecules. Biological systems exhibit intricate and dynamic behaviors, making traditional optimization methods often inadequate. This algorithm addresses this limitation by incorporating a self-adjustment mechanism that...
Protein folding is a fundamental biological process, and achieving accurate and stable folding is critical for protein function. Current methods often struggle to preserve the intricate network of interactions within the protein structure, leading to misfolded proteins and disease. This paper introduces a novel Dynamic...
Background: Mesenchymal stromal cell-derived conditioned medium (MSC-CM) represents a promising cell-free approach for regenerative medicine; however, variability in production conditions remains a major challenge for standardization. This study investigated how serum-free conditioning duration influences the proteomic...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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