Motivation. Variant effect predictions are most interpretable when read against structure, and this is already available for human proteins: the AlphaFold database displays AlphaMissense pathogenicity as a residue-level heat map on the predicted fold, and proteome-wide language model predictions have been published wit...
Rashid Karim· Zenodo (CERN European Organi...· 0 citations
In vitro findings help contextualize why the clinically observed lag in parasite clearance may be temporally distinct from symptomatic improvement, including fever resolution, and present cabamiquine as a fast-acting, slow clearing antimalarial drug.
Claudia Demarta-Gatsi, J. Wallner, S. K. Dhingra et al.· Antimicrobial Agents and Che...· 0 citations
Detecting target molecules in complex samples with both high sensitivity and selectivity remains a central challenge in biosensing, owing to low analyte abundance and interference from coexisting substances. Here, we present a membrane scaffold based on a ZZ-tag-displaying hepatitis B virus-derived L protein (ZZ-L me...
Candida auris (C. auris) is a rapidly emerging, multidrug-resistant fungal pathogen whose persistence is partly driven by adhesion to host tissues and abiotic surfaces. Surface-colonization factor 1 (Scf1) is a C. auris-specific adhesin implicated in surface adhesion, biofilm formation, virulence, and persistence in he...
Pratik Vyas, Jiajun Li, Rosario Vanella et al.· bioRxiv (Cold Spring Harbor...· 0 citations
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Casein, the primary source of protein in ruminant milk, represents a family of proteins that self-assemble into globules composed of finer spherical subunits and stabilized by calcium phosphate (CP) nanoparticles. These globules act as holdase-type chaperones for unfolded or partially folded proteins, preventing their...
V. Uskoković, Michael Ibba, L. Leiva· ACS Applied Bio Materials· 0 citations
The fungal plant pathogen Sphaerulina musiva (Ascomycota) causes Septoria stem canker, the most economically damaging disease of Populus plantations in North America, yet the genetic determinants of host resistance remain uncharacterized in hybrid poplar. Using an inoculation experiment with the 52-124 pseudo-backcross...
Kyle Mondron, Susanna Kerio, K. Søndreli et al.· Phytopathology· 0 citations
This work presents a theoretical development program for a single-administration adeno-associated virus (AAV) gene therapy designed to treat chronic kidney disease (CKD) in the domestic cat. The approach centers on the delivery of an affinity-detuned variant of feline Apoptosis Inhibitor of Macrophage (m-fAIM), enginee...
Marco Troisi· Zenodo (CERN European Organi...· 0 citations
INTRODUCTION. Zirconium dioxide (ZrO
2
) is among the most widely used materials for fixed dental prostheses, and the reliability of adhesive luting largely depends on surface cleanliness. Contact of the framework with mixed saliva during try-in results in adsorption of organic components that reduces bond strength...
R. Meremkulov, Z. Khabadze, E. M. Kakabadze et al.· Endodontics Today· 0 citations
Considering the increasing worldwide prevalence of Type 2 diabetes mellitus (T2DM), utilizing milk protein-derived bioactive peptides offers a promising and sustainable solution to manage hyperglycemia. However, formulating functional foods rich in Dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides is hindered by the...
B. Ashritha, Sathish Kumar M.H., Manoj Kumar C.T. et al.· Figshare· 0 citations
The combined analyses reveal that perturbation of H2A.Z is sufficient to alter H3K27me3 homeostasis in a locus-specific fashion and are consistent with the possibility of a functional relationship between these conserved chromatin features in plants.
The results support protein variability as an additional analytical dimension alongside fold-change analysis for describing proteome instability and tumor heterogeneity and provides an additional framework for characterizing tumor proteome heterogeneity.
Arina I. Gordeeva, Anna A. Kliuchnikova, A. Kozlova et al.· International Journal of Mol...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
