Alocasia macrorrhizos is an underutilized starch source with limited industrial application due to low starch yields reported in previous studies and insufficient physicochemical characterization. In this study, a NaCl-based starch extraction process from A. macrorrhizos corms was optimized using Response Surface Metho...
Biswanath Karmakar, Mouriya Aich, Shyama Prasad Saha et al.· Scientific Reports· 0 citations
Overview This paper addresses the P versus NP problem by proposing a fundamental epistemological and geometric rupture. Rather than treating the "combinatorial explosion" characteristic of NP problems as an intrinsic physical or mathematical barrier, this work demonstrates that it is an artifact of measuring a multi-di...
Cláudio Vicente da Silva· Zenodo (CERN European Organi...· 0 citations
Drought is a major limiting factor in cotton ( Gossypium hirsutum L.) cultivation, particularly in semi-arid regions, where water scarcity hinders plant growth. This study investigated the effects of rhizobacteria on the morphological and physiological responses of cotton plants under water stress. The experiment was c...
Ellie José Pereira, Vinícius de Souza, Caliane da Silva Bráulio et al.· BMC Microbiology· 0 citations
IntroductionWe investigated two siblings from a consanguineous Kurdish family presenting with a specific facial phenotype (prominent forehead, supraorbital ridges, broad nose, depressed nasal bridge), severe short staturewith biochemical features of growth hormone (GH) deficiency, microcephaly, and developmental delay....
figshare admin karger, Shenali Anne Amaratunga, Martin Bezdicka et al.· Figshare· 0 citations
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This study investigated retinal proteomic alterations associated with type-1 diabetes mellitus (T1DM) using two mouse models of diabetic retinopathy (DR): the genetic Ins2akita/+ (Akita) model and streptozotocin (STZ)-induced diabetes. Retinas were collected from Akita (n = 4) and STZ-induced diabetic mice (n = 6) 15–1...
STING-mediated JAK-STAT suppression is identified as a novel mechanism of immune dysfunction in aging PLWH, proposing targeted STING inhibition as a potential therapeutic strategy to improve immune recovery in this vulnerable population.
Na Li, Hong-Yi Zheng, Xia Li et al.· Immunity & Ageing· 0 citations
Findings support an important role for the Rip-2 C-terminal Phe18 aromatic residue in the enhanced activity of this peptide relative to thanatin and provide a framework for the rational design of more potent thanatin-derived antibiotics.
P. Panteleev, V. Safronova, Julia S. Teplovodskaya et al.· International Journal of Mol...· 0 citations
The results suggest that iron differentially regulates Tv-CatD at the posttranscriptional level, possibly through RNA-protein complexes, and at the posttranslational level, possibly through direct binding to the catalytic domain.
Lizbeth Sánchez-Ayala, Marisol Castillo-Leyva, J. Ortega-López et al.· Biometals· 0 citations
These previously unknown TF conformations provide a structural basis for maintaining the encrypted and decrypted states of TF on the cell surface and were validated by Molecular Dynamics simulations.
IntroductionWe investigated two siblings from a consanguineous Kurdish family presenting with a specific facial phenotype (prominent forehead, supraorbital ridges, broad nose, depressed nasal bridge), severe short staturewith biochemical features of growth hormone (GH) deficiency, microcephaly, and developmental delay....
figshare admin karger, Shenali Anne Amaratunga, Martin Bezdicka et al.· Figshare· 0 citations
Globular proteins are difficult to convert into robust hydrogels, as their compact, folded structures bury reactive residues, forcing conventional strategies to rely on denaturation or synthetic-polymer reinforcement that compromise the native protein. Inspired by the beta-ketoenamine bond-forming chemistry of covalent...
Optogenetic dimerization modules are widely used to regulate protein function, yet their behaviour within folded enzymes remains incompletely understood. Here, we engineered vesicular stomatitis virus by inserting an intramolecularly tethered light-inducible dimerizer into the viral RNA-dependent RNA polymerase [large...
Maino Tahara, T Kameya, Hideki Tani et al.· Journal of General Virology· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
