This repository includes a theoretical extension of the General Epistemic Dispersion Theory (GEDT) formalism to the domain of molecular biology, using adult human hemoglobin (HbA) as a case study. The manuscript proposes a bio-epistemic mapping in which the acquisition of the three-dimensional configuration is analyzed...
Massimo Comitato· Zenodo (CERN European Organi...· 0 citations
Endoplasmic reticulum stress (ERS) arises when the protein-folding load, or perturbations in calcium and redox homeostasis, outpace the adaptive capacity of the endoplasmic reticulum (ER). The unfolded protein response (UPR) initially reduces secretory load and restores proteostasis. Persistent stress can redirect the...
Jia-Xi Qiao, Jia Chen, Jin-Bo Chen et al.· Frontiers in Immunology· 0 citations
FINDING: Icosahedral symmetry in viral capsids is a direct physical realization of the rotational group \( A_5 \) (order 60), constrained by quasi-equivalence (Caspar–Klug theory) to specific triangulation numbers \( T = h^2 + hk + k^2 \). | MATH: Caspar–Klug triangulation number \( T = h^2 + hk + k^2 \) (h,k non-negat...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
Protein stability, the capacity to maintain a folded structure and function, matters as much for transporters and regulators as for enzymes, and heat erodes it. Wheat, rice, maize and soybean supply two-thirds of human caloric intake, and warming reduces yields. Rubisco activase variants selected for thermostability in...
Decentralized diagnostics are vital for infectious disease control, yet current point-of-care tools remain largely one-dimensional, failing to capture the multidimensional profiles required for precision management. Here, we show SID-WAVES (Smartphone-Integrated Diagnostics with Wax-encoded Amplified and Versatile Eval...
Tao Xu, Ying Zhang, Xin Tang et al.· Nature Communications· 0 citations
Bone metastases (BoM) develop in 60–90% of men with advanced prostate cancer (PCa) and are associated with a significantly decreased quality of life and 5-fold increased risk of mortality. However, current frontline treatments offer only marginal improvements in survival and symptom management. In this study, we invest...
ABSTRACT HIV-1 CRF01_AE Cluster 4 strains are spreading rapidly in China and Southeast Asia, yet the molecular characteristics and pathogenic mechanisms remain to be fully characterized. Here, we identified a characteristic RSSL tetrapeptide deletion in the gp41 region of CRF01_AE Cluster 4 strains. Compared with a Clu...
Dong Zhang, Jing-Wan Han, Chang Liu et al.· Journal of Virology· 0 citations
OBJECTIVES
To determine whether serum inflammatory markers, Erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP), varied according to pathogen profile in patients with confirmed fracture-related infection (FRI).
METHODS
Design: Retrospective Cohort Study.
SETTING
Single, multi-site urban academic insti...
Abhishek Ganta, Lauren A. Merrell, Natalie H. Vu et al.· Journal of Orthopaedics and...· 0 citations
Temperature-dependent small- and wide-angle x-ray scattering is developed as a probe of biomolecular structure, dynamics, and interactions in the solution phase and applied to two well-characterized model proteins: the Villin headpiece subdomain and the GB3 domain to provide real-space fingerprints of the folds that pl...
H. Cho, F. Schotte, John M. Louis et al.· Journal of Chemical Physics· 0 citations
Triangular attention is a core computation in AlphaFold3-style biomolecular models, with cubic cost in token count. Its shared pair bias adds a gradient reduction across attention slices to the usual reductions over queries and keys. The open-source backends we examine handle these reductions through repeated probabili...
Yi-De Ran, Chelsea Lowman, J. Domanski et al.· 0 citations
We propose D-DOIT (Discrete Doob-Oriented Inference-time Transformation), a training-free and efficient adaptation method for discrete diffusion models with generic rewards. D-DOIT formulates adaptation as sampling from a reward-tilted target distribution and realizes this transport through Doob's h-transform of the di...
Jie-Ke Wu, Qi-Jie Zhu, Wei-Min Wu et al.· 0 citations
Protein binding prediction is central to target identification, therapeutic binder design, and large scale screening, yet remains challenging because binding depends on sequence, three dimensional geometry, and global structural organization. Recent folding models such as AlphaFold3 and Boltz-2 have substantially impro...
Jae Won Choi, Ryoonki Hong, Alan Liang et al.· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
