Bipolar disorder (BD) is highly heritable, yet the contribution of rare coding variation remains incompletely characterized. We analyzed sequencing data from 64,435 individuals with BD and 168,101 controls spanning multiple ancestries and 22 countries, representing the largest and most global sequencing resource with a...
C. Liao, R. Ye, J. Sealock et al.· medRxiv· 0 citations
Objective: Rare STAB2 loss-of-function variants emerged in population studies as being associated with elevated venous thromboembolism (VTE) risk. STAB2 encodes the cell-surface scavenger receptor stabilin-2, and reduced stabilin-2 function might increase VTE risk via elevated plasma levels of its ligands, including vo...
R. Adam, A. Jordan, T. Valovka et al.· medRxiv· 0 citations
It is shown that, in the presence of rapid “minor-exchange”, the apparent minor-state chemical shift obtained from two-state fits varies systematically with the static magnetic field, B0, and this field dependence is exploited to develop a nonperturbative, multi-field CEST strategy that distinguishes otherwise degenera...
V. P. Tiwari, Laetitia Rožić, Sebastian Hiller· Journal of the American Chem...· 0 citations
Objective: This study aimed to identify a central molecular target associated with hepatocellular carcinoma (HCC) using bioinformatic methods and to comparatively evaluate the binding potential of reference inhibitors and natural compounds against this target by molecular docking.Materials and Methods: In the GSE76427...
Z. Kucukakcali, İpek Balıkçı Çiçek· ODÜ Tıp Dergisi· 0 citations
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Secretion of recombinant proteins from microbial cell factories is a promising strategy for recombinant protein biomanufacturing as it simplifies downstream processing. In this study, we sought to intensify the Lactococcus lactis high-cell-density culture, using basic fibroblast growth factor 2 (FGF2) as a model recomb...
Prashant Mainali, Jin-Hao Tan, P. Ho et al.· Microorganisms· 0 citations
Low-populated protein excited states can play decisive roles in function, ligand recognition, and misfolding, but their structural characterization remains difficult because these conformations are transient and sparsely populated. Here, we present CS-SelectFold, a framework that combines generative conformational sa...
Wan-Jia Tang, Qian-Qian Wang, Xiong-Jie Xiao et al.· Journal of Chemical Informat...· 0 citations
Gallstone disease is a common biliary disorder forwhich non-invasive, ultrasonography-independent risk assessmentmay support clinical decision-making. This study proposesan ANOVA–Mutual Information (ANOVA–MI) feature-selectionframework combined with CatBoost, evaluated on 319 patientsand 38 candidate predictors from th...
Interleukin-38 (IL-38), an anti-inflammatory IL-1 superfamily member, is paradoxically elevated in Rheumatoid Arthritis (RA). Whether this reflects pathogenic involvement or compensatory counter-regulation remains unresolved. Co-measuring Protein Tyrosine Phosphatase Non-Receptor (PTPN22) expression offers a unique opp...
Yasir Chnani, Rafid Abdulkarrem· Egyptian Rheumatology and Re...· 0 citations
Volume C of the Ontology-First N.E.A. Series. Complex systems, topological value, and the enthalpy bank. The physical mainline of the Ontology-First N.E.A. Series derives the entire universe — spacetime, matter, forces, particles, atoms, cosmology, and the observer — from a single logical primitive operating under the...
Yu Zhang· Zenodo (CERN European Organi...· 0 citations
Background and Objectives: Influenza A virus remains a major global health concern because antigenic drift reduces the long-term efficacy of current vaccines. This study evaluated a multi-epitope DNA vaccine targeting conserved regions of hemagglutinin (HA) and polymerase acidic (PA) proteins from influenza A/H1N1 and...
K. Barkhordari, F. Rezaei, V. Salimi et al.· Iranian Journal of Microbiol...· 0 citations
The Sigma-1 receptor (S1R) is a ligand-regulated membrane protein whose pathogenic variants are associated with motor-neuron and neurodegenerative disorders, yet its ligand conformational selectivity and receptor organization remain incompletely understood. We systematically characterized 35 pathogenic or likely pathog...
Nikola Mitović, Nina Japundžić‐Žigon, Marija Stanojević et al.· Zenodo (CERN European Organi...· 0 citations
Background and Objectives: The global rise of antimicrobial resistance threatens effective treatment of bacterial infec- tions. Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen whose resistance to β-lactam antibiotics is primarily mediated by the mecA gene, encoding the low-affinity penicillin-bi...
Arooj Khan, Adnan Iqbal, Husnain Athar et al.· Iranian Journal of Microbiol...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
