The CRISPR-Cas9 system revolutionized genome editing and is a very promising platform for the treatment of cancers, genetic disorders, and infections. Yet the clinical translation of CRISPR-Cas9 is hampered by some major bottlenecks related to delivery issues, such as fast degradation, poor cellular uptake, and immunog...
Tushar Ingle Shubhangi Lal· Zenodo (CERN European Organi...· 0 citations
Chronic HBV won't be resolved in the immediate future. Almost 300 million individuals live with it [1], as well as it causes roughly 820,000 deaths annually [1]—mainly due to conditions such as cirrhosis, liver failure, or liver cancer. The usual therapies, such as nucleos(t)ide analogues and pegylated interferon-alpha...
Ponuku Sandhya, Guduri Sathwika, Nuli Sai Vasavi Taruni, S.V. Saikumar· Zenodo (CERN European Organi...· 0 citations
RNA editing in mitochondria is vital for many eukaryotes. In plants, mitochondrial C-to-U deamination editing is catalyzed by tens to hundreds of PPR-DYW proteins, each typically dedicated to a specific site. Where retained, PPR-DYW family expanded independently in all eukaryotic groups. Marine microeukaryotes diplonem...
Matus Valach, Gertraud Burger, B. Franz Lang· Figshare· 0 citations
Salinity and drought stresses induced by climate change pose critical threats to global food security, necessitating a comprehensive insight of plant adaptive mechanisms at the genomic level. This review brings together recent advances in identifying genes, regulatory networks, and evolutionary strategies underlying pl...
Md. Arif Sakil, S. Shorna, Maisha Rahman et al.· OBM Genetics· 0 citations
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RNA editing in mitochondria is vital for many eukaryotes. In plants, mitochondrial C-to-U deamination editing is catalyzed by tens to hundreds of PPR-DYW proteins, each typically dedicated to a specific site. Where retained, PPR-DYW family expanded independently in all eukaryotic groups. Marine microeukaryotes diplonem...
Matus Valach, Gertraud Burger, B. Franz Lang· Figshare· 0 citations
The CRISPR-Cas9 system revolutionized genome editing and is a very promising platform for the treatment of cancers, genetic disorders, and infections. Yet the clinical translation of CRISPR-Cas9 is hampered by some major bottlenecks related to delivery issues, such as fast degradation, poor cellular uptake, and immunog...
Tushar Ingle Shubhangi Lal· Zenodo (CERN European Organi...· 0 citations
Light is shed on TCF4 as a key regulator of neural crest-derived lineages that contribute to craniofacial and Enteric Nervous System development and a new perspective on two major clinical features of PTHS is provided.
M. Orefice, Francesca Remondino, Irene Pieraccioni et al.· Frontiers in Cell and Develo...· 0 citations
Viral hepatitis is a major global health problem, being the leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma. The World Health Organization (WHO) has reported that hepatitis B and C viruses cause 1.34 million deaths yearly, and despite the availability of effective vaccines and treatments...
Multiple myeloma (MM) is a genetically heterogeneous plasma cell malignancy characterized by recurrent chromosomal abnormalities and progressive genomic instability. Among these, the t(4;14)(p16;q32) defines a high-risk molecular subtype associated with poor clinical outcomes despite advances in therapy. This transloca...
Hamidreza Galavi· cIRcle (University of Britis...· 0 citations
Domestication and industrial breeding have delivered major productivity gains but cost livestock a significant portion of their ancestral gut microbiota. This depletion is linked to reduced digestive efficiency, weaker disease resistance, and compromised metabolic health. A parallel insight from crop science—that “rewi...
Chun-Hui Zhang, Xin-Quan Zhao· The Innovation Life· 0 citations
It is demonstrated that dual editing of BcSGR1 and BcSGR2 exerts an additive effect on delaying leaf senescence and enhances postharvest shelf life without incurring significant yield penalties under the experimental conditions.
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
