gene editing

Rice immunity against Asian rice gall midge: from resistance genes to precision breeding

Species-specific loss of chloroplast ndhB -872 RNA editing in tea and tomato is caused by impaired QED1 mediated MORF recruitment

The functional necessity of ndhB-872/QED1 co-evolution in tea and tomato, elucidate the critical role of ndhB-872 editing in tomato photosynthetic homeostasis, and offer promising methods for targeted manipulation of ndhB-872 editing in crop improvement are revealed.

A-to-I RNA editing profiles and distinct immune responses in myelin oligodendrocyte glycoprotein antibody-positive optic neuritis

Introduction Myelin oligodendrocyte glycoprotein antibody-positive optic neuritis (MOG-ON) is an autoimmune inflammatory demyelinating disorder of the optic nerve that often results in severe visual impairment and recurrent attacks. Although immune dysregulation is recognized as a central feature of MOG-ON, the contrib...

The inspiration of CRISPR-Cas: Interface of nature with a pharmacy: A compatible horizon of cancer treatment

Cancer has always been a complicated disease to understand and treat since it has complex genetic factors, heterogeneity of tumors, resistance to treatment, and metastasis. The traditional treatments of chemotherapies are associated with systemic side effects, whereas targeted therapies and conventional immunotherapies...

Belajar Tentang Agent Biologis -- Agent Biologis: A to Z

Mengapa buku ini dibutuhkan Terapi biologis berkembang pada pertemuan biologi molekuler, imunologi, genetika, biomaterial, manufaktur, uji klinis, regulasi, dan etik. Kompleksitas ini sering menimbulkan dua kesalahan ekstrem: menolak inovasi hanya karena belum familiar, atau menerima klaim hanya karena teknologi tampak...

CCR5 as a Therapeutic Target in HIV Disease: From CRISPR/Cas9 Gene Editing to Maraviroc-Mediated Inhibition

The molecular mechanisms, preclinical evidence and emerging clinical data supporting CRISPR-based CCR5 disruption, including multiplex editing strategies designed to overcome viral tropism switching, and the evolving role of maraviroc beyond viral entry inhibition are examined.

Spatial transcriptomics reveals laminar and cell-type-specific A-to-I RNA editing signatures in the macaque cortex

ADAR-mediated A-to-I RNA editing is crucial for proper neuronal function. However, its spatial signatures in the cerebral cortex remain largely unexplored. To address this, we developed SRDRE, an analysis framework for identifying RNA editing sites in spatial transcriptomics data. By analyzing over 40 million cells acr...

Targeting Piezo1/2 ion channels for modulation of the lymphatic system: mechanisms, applications, and therapeutic prospects

This review comprehensively summarizes approaches targeting Piezo1/2, including the development of small-molecule agonists/inhibitors, gene-editing technologies, physical modulation methods, and advanced drug delivery systems, as well as their research progress and clinical prospects.

Artificial intelligence-guided engineering of precision ocular therapeutics.

PURPOSE OF REVIEW This review surveys recent advances in artificial intelligence-guided small molecule discovery and gene therapy, with a focus on generative and foundation models, and their translational applications to ophthalmic therapeutics. RECENT FINDINGS A unifying theme across recent work is the shift from ar...

Commentary: Epitranscriptomic regulation by m6A in immunity and autoimmune disorders: emerging mechanisms and clinical perspectives

therefore move beyond merely acknowledging context dependence and instead establish testable, context-resolved frameworks for mechanistic validation and clinical translation.A major risk in current studies of m6A in autoimmune diseases is the overinterpretation of regulator expression. Altered expression of METTL3/METT...

Mechanisms and therapeutic insights from zebrafish models of wound healing

Wound healing is essential for tissue integrity, yet chronic wounds remain a significant clinical challenge. The zebrafish ( Danio rerio ) offers unique advantages for studying wound repair: optical transparency enables real-time in vivo imaging, robust regenerative capacity allows scarless tissue restoration, an...

Make sorghum great again: navigating the politics of gene editing in the Make America Healthy Again movement

Gene editing has emerged as a promising tool for developing climate-resilient crops, yet discussions of its adoption have focused primarily on technological performance and public acceptance, while paying less attention to the political realignments that increasingly shape agricultural innovation. The emergence o...