OBJECTIVES
Candida parapsilosis is a leading cause of invasive candidiasis globally, with rising reports of fluconazole resistance threatening its clinical management. Among the mechanisms involved, gain-of-function mutations in the MRR1 gene have emerged as key drivers of antifungal resistance. We aimed to investigate...
Manon Cadeau, José Rivaldo de Lima, Alina Marcela-Sabou et al.· Medical Mycology· 0 citations
Cancer remains among the leading causes of death worldwide, with an estimated 20 million new cases and nearly 10 million deaths in 2022 and a burden projected to grow substantially over the coming decades [1]. The conceptual framework of cancer as a disease of dysregulated hallmark capabilities, sustained proliferation...
Ximena Maria Mureșan, Adrian Bogdan Tigu, Andrei Roman et al.· Frontiers in Pharmacology· 0 citations
Chronic hepatitis B virus (HBV) infection remains a major global health challenge, affecting over 250 million individuals and causing more than one million deaths annually from cirrhosis and hepatocellular carcinoma. Although current antiviral therapies effectively suppress viral replication, they rarely achieve a func...
Saniya Sanjaysinh Patil, Siddhi Shivaji Powar, Shruti Vilas Patil, Prathamesh Pundlik Khade· Zenodo (CERN European Organi...· 0 citations
This review dissects tobamovirus genome biology, and highlights the epidemiology of the emerging ToBRFV as a case study, along with an overview of detection and surveillance tools for tobamoviruses.
While previous reviews have largely focused on individual crops or single target-site mechanisms, the full-chain comparative landscape across major cereal crops remains unexplored. Here, we fill this critical gap by providing the first systematic, cross-crop comparative review that spans herbicide targets, resistance m...
Yong-Chao Guo, Xue-Xia Ma, Zi-Hang Li et al.· Plants· 0 citations
Rhesus (Rh) family B glycoprotein (RHBG) is a conserved ammonium transporter of the Rhesus family with established roles in systemic acid-base regulation. Although Rh family members are expressed in the male reproductive tract, the physiological role of RHBG in spermatogenesis and sperm function remains unclear. To inv...
Guang-Qing Tan, Lu-Jie Chen, Ru-Xiang Yang et al.· Asian Journal of Andrology· 0 citations
Chronic HBV won't be resolved in the immediate future. Almost 300 million individuals live with it [1], as well as it causes roughly 820,000 deaths annually [1]—mainly due to conditions such as cirrhosis, liver failure, or liver cancer. The usual therapies, such as nucleos(t)ide analogues and pegylated interferon-alpha...
Ponuku Sandhya, Guduri Sathwika, Nuli Sai Vasavi Taruni, S.V. Saikumar· Zenodo (CERN European Organi...· 0 citations
The functional interpretation of infrequent somatic variants remains a challenge in cancer genomics. We developed CRISPR-VUS, a computational framework using public Cancer Dependency Map data to identify Dependency-Associated Mutations (DAMs) - somatic variants associated with increased dependency on their host genes -...
Despite remarkable progress in prevention and treatment, hepatitis is still one of the main drivers of chronic liver disease, liver cirrhosis and hepatocellular carcinoma and is a big public health problem worldwide. The hepatitis viruses A, B, C, D and E are responsible for the occurrence of viral hepatitis in million...
Bhushan H. Jogawe, Unnati K. Bhagade, Suraj D. Thakare· Zenodo (CERN European Organi...· 0 citations
The CRISPR-Cas9 system revolutionized genome editing and is a very promising platform for the treatment of cancers, genetic disorders, and infections. Yet the clinical translation of CRISPR-Cas9 is hampered by some major bottlenecks related to delivery issues, such as fast degradation, poor cellular uptake, and immunog...
Tushar Ingle Shubhangi Lal· Zenodo (CERN European Organi...· 0 citations
The CRISPR-Cas9 system revolutionized genome editing and is a very promising platform for the treatment of cancers, genetic disorders, and infections. Yet the clinical translation of CRISPR-Cas9 is hampered by some major bottlenecks related to delivery issues, such as fast degradation, poor cellular uptake, and immunog...
Tushar Ingle Shubhangi Lal· Zenodo (CERN European Organi...· 0 citations
This study examines public attitudes toward gene-edited foods in Japan, focusing on how underlying worldviews shape these responses. Drawing on a national survey and a latent class segmentation model based on 23 worldview variables, we identify four distinct segments: Communitarian, Environmentalist, Governmentalist, a...
Tomiko Yamaguchi, 나일등· Public Understanding of Scie...· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
