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gene editing

1,409 papers

#gene editing Open access Sep 2026

A Novel Lipid Nanoparticle (LNP) Matrix Formulation (60:20:18:2) Incorporating Synthetic gRNA and Modified mRNA Sequences for Universal Cellular Receptor Blockade and Accelerated Somatic Hypermutation

महा इम्यूनिटी सूत्र (MHA Immunity Sutra): वायरस के खिलाफ इंसानी शरीर का नया सुरक्षा कवचआविष्कारकर्ता (Inventor): बंटी कुमावतकल्पना कीजिए एक ऐसी दुनिया की जहाँ "महामारी" (Pandemic) शब्द का नामोनिशान ही मिट जाए। एक ऐसी दुनिया जहाँ कोई भी नया, पुराना या रूप बदलने वाला वायरस जैसे ही किसी इंसान के शरीर को छुए, वहीं पर बेअसर...

Banti Kumawat · 0 citations
#gene editing Open access Sep 2026

Molecular characterization of required for killing-2: a gene required for spore killing by Neurospora Sk-3

The Sk-3 selfish genetic element in Neurospora fungi is transmitted to offspring in a biased manner through spore killing. In crosses between an Sk-3 strain and a Spore killing-sensitive (Sk-S) strain, nearly all offspring that fail to inherit Sk-3 are killed. Although a mutation called rfk-2UV, which disrupts spore ki...

Sabiha Sultana, Shahriar Mahmud, Parham Jazireian et al. · 0 citations
#gene editing Open access Sep 2026

A Novel Lipid Nanoparticle (LNP) Matrix Formulation (60:20:18:2) Incorporating Synthetic gRNA and Modified mRNA Sequences for Universal Cellular Receptor Blockade and Accelerated Somatic Hypermutation

महा इम्यूनिटी सूत्र (MHA Immunity Sutra): वायरस के खिलाफ इंसानी शरीर का नया सुरक्षा कवचआविष्कारकर्ता (Inventor): बंटी कुमावतकल्पना कीजिए एक ऐसी दुनिया की जहाँ "महामारी" (Pandemic) शब्द का नामोनिशान ही मिट जाए। एक ऐसी दुनिया जहाँ कोई भी नया, पुराना या रूप बदलने वाला वायरस जैसे ही किसी इंसान के शरीर को छुए, वहीं पर बेअसर...

Banti Kumawat · 0 citations
#gene editing Open access Sep 2026

Genetic Engineering and CAR-T Cell Therapy inHematological Malignancies: From CD19/BCMATargeting to CRISPR-Enabled Cellular Engineering

This research provides a comprehensive overview of genetic engineering and chimeric antigen receptor T-cell (CAR-T) therapy in the treatment of hematological malignancies. It examines the development of CAR-T cell therapies targeting clinically important antigens, particularly CD19 and B-cell maturation antigen (BCMA),...

Zeeshan Qaiser · 0 citations
#gene editing Review Open access Sep 2026

EMERGING APPLICATIONS OF CRISPR–CAS9 BEYOND GENE EDITING

This review discusses about the mechanism followed by CRISPR CAS9 in gene editing and various other possible applications of CRISPR CAS9.

Amaan Hussain Gouri, Khushmanpreet Kaur, Abhishek Sharma et al. · 0 citations
#gene editing Open access Sep 2026

Mitoxyperilysis-ARDS: analysis code, six-layer gene signature, and frozen statistical outputs for "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (archive v4; manuscript v2.30)

This archive supports the manuscript "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (submission target: Critical Care, BMC; manuscript version v2.30, September 2026). Contents: (1) complete analysis code (R 4.6.1 / Pyt...

Huangwei Lin, Yuanshui Liu · 0 citations
#gene editing Open access Sep 2026

Genetic Enhancement – CRISPR & Human Performance

This review paper explores the potential of CRISPR-Cas9 gene-editing technology to enhance human performance across muscular, metabolic, and neurocognitive domains. It synthesizes the genetic mechanisms (such as ACTN3, MSTN, EPOR, and BDNF), clinical applications, safety risks, and ethical considerations surrounding hu...

OMAR MOHAMMAD OMAR MOHAMMAD ALKHAZALEH · 0 citations
#gene editing Open access Sep 2026

Genetic Engineering and CAR-T Cell Therapy inHematological Malignancies: From CD19/BCMATargeting to CRISPR-Enabled Cellular Engineering

This research provides a comprehensive overview of genetic engineering and chimeric antigen receptor T-cell (CAR-T) therapy in the treatment of hematological malignancies. It examines the development of CAR-T cell therapies targeting clinically important antigens, particularly CD19 and B-cell maturation antigen (BCMA),...

Zeeshan Qaiser · 0 citations
#gene editing Open access Sep 2026

Genetic Enhancement – CRISPR & Human Performance

This review paper explores the potential of CRISPR-Cas9 gene-editing technology to enhance human performance across muscular, metabolic, and neurocognitive domains. It synthesizes the genetic mechanisms (such as ACTN3, MSTN, EPOR, and BDNF), clinical applications, safety risks, and ethical considerations surrounding hu...

OMAR MOHAMMAD OMAR MOHAMMAD ALKHAZALEH · 0 citations
#gene editing Open access Sep 2026

Mitoxyperilysis-ARDS: analysis code, six-layer gene signature, and frozen statistical outputs for "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (archive v5; manuscript v2.30)

This archive supports the manuscript "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (submission target: Critical Care, BMC; manuscript version v2.30, September 2026). Contents: (1) complete analysis code (R 4.6.1 / Pyt...

linhuangwei, Yuanshui Liu · 0 citations
#gene editing Open access Sep 2026

Long Non-Coding RNAs in Fish Reproduction: Emerging Regulators from Gonadal Fate to Fertility

Long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression acting through transcriptional, post-transcriptional, and epigenetic mechanisms. In teleosts, high-throughput sequencing has identified a growing number of lncRNAs associated with gonadal development and reproductive function, yet cu...

Beatriz Marques de Souza, Amanda de Oliveira Ribeiro, Maira da Silva Rodrigues et al. · 0 citations
#gene editing Open access Sep 2026

APOE 4/4 promotes dysfunctional and inflammatory phenotypes concomitant with impaired maturation of hiPSC-derived astrocytes

The results indicate that APOE 4/4 alters astrocyte morphological and molecular maturation while promoting inflammation, disturbing glutamate and Aβ handling under basal conditions and suggests that APOE ε4/ε4 genotype disrupts astrocyte development and key processes of cellular homeostasis early in Alzheimer’s disease...

Rebeca Vecino, Eva Díaz-Guerra, E. Arribas-González et al. · 0 citations

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