Mutations in the splicing factor SRSF2 are commonly found in healthy individuals with clonal hematopoiesis (CH), where they confer a high annual clonal growth rate and an elevated risk for MDS/AML transformation [ 1 ]. Accordingly, SRSF2 mutations frequently occur in patients with myelodysplastic neoplasms (MDS, 10-15%...
Johannes Foßelteder, Gabriel Pabst, Andrea Raicht et al.· Leukemia· 0 citations
functional-standard-atlas: attenuation-corrected, territory-resolved benchmarking of variant effect predictors against saturation genome editing Software and frozen data underlying the manuscript "Measurement reliability bounds functional benchmarks and relocates where variant effect prediction fails" (N. Zhang). WHAT...
Ranking is saturated, calibration is not, and neither changes the evidence strength — code and frozen analysis set Software and frozen data underlying the manuscript "Ranking is saturated, calibration is not, and neither changes the evidence strength: an independent benchmark of splice-region variant effect predictors...
Ningyi Zhang· Zenodo (CERN European Organi...· 0 citations
Efficient biosynthesis of 1,3-PDO, a key bio-based chemical, depends on precise regulation of the host metabolic network. In this study, a heterologous CRISPR-Cas12a genome editing system was established and systematically optimized in Klebsiella pneumoniae, enabling efficient and stable genome editing (75-100% efficie...
Li Wang, Ming-Yang Zhao, Yuan-Ming Ye et al.· Bioresource Technology· 0 citations
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Systematic comparison of Cas12i gene-editing tools in tomato identifies Cas-SF01 as the most efficient variant, achieving editing efficiencies comparable to conventional Cas9 at some genomic sites and providing a compact, highly specific, and versatile tool for studying gene function, engineering fruit metabolism, and...
Si-Qun Wu, Lei Zhu, Mei-Li Zhou et al.· Journal of Integrative Plant...· 0 citations
ABSTRACT Lignin is a major constituent of lignocellulose and the most abundant aromatic biopolymer on earth. It provides plants with rigidity and protection, but its recalcitrant nature also presents a significant barrier to lignocellulose valorization. The white-rot fungus Phanerochaete chrysosporium is among nature’s...
Hao Wu, Jiao-Jiao Zhang, Yi Zhao et al.· Applied and Environmental Mi...· 0 citations
The results showed that higher runx2 b promoter methylation patterns significantly inhibited eGFP mRNA expression levels in the recombinant plasmid, and this approach provides a theoretical foundation and technical support for improving fish economic traits.
Fang Liang, Bi-Yu Wu, Jia-Yi Liu et al.· Zoological Research· 2 citations
Micronutrient malnutrition remains a major global nutrition problem, particularly in populations whose diets depend heavily on staple crops. Iron (Fe), zinc (Zn), and vitamin A deficiencies can adversely affect growth, immunity, cognitive development, and overall health. Crop biofortification provides a sustainable b...
Alemayehu Latera, E. Estifanos· iResearch· 0 citations
The CRISPR-Cas9-mediated deletion of endogenous retrovirus-derived cis-regulatory elements in human naive pluripotent stem cells enables direct functional interrogation of species-specific non-coding regulatory sequences and supports the study of transcriptional mechanisms involved in early human development.
Yun-Ying Huang, Merel Wentink, R. Fueyo· Journal of Visualized Experi...· 0 citations
Where genetic accessibility can be established, the integration of CRISPR technology with synthetic biology may enable more precise gene regulation and could support the development of next-generation engineered Bifidobacterium-based platforms.
Cancer remains a major global health challenge due to its genetic complexity, tumor heterogeneity, and the development of therapeutic resistance.Conventional treatment modalities, including surgery, chemotherapy, immunotherapy, and radiotherapy, often fail to completely eradicate malignant cells and may cause significa...
Mahmood S. Choudhery, Taqdees Arif, Ruhma Mahmood et al.· WArtificial Intelligence in...· 0 citations
BMAL1 is a core circadian transcription factor that also regulates stem cell fate, yet its role in human embryonic stem cell neurodifferentiation remains incompletely understood. Circadian disruption is associated with adverse neurodevelopmental outcomes, while N6 methyladenosine (m6A) RNA modification is a key regulat...
Bing Cai, Tianrui Wen, Boyan Wang et al.· Genome biology· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
