A substantial increase in the global burden of CVDs is demonstrated, with prevalence nearly doubling between 1990 and 2019 and mortality continuing to rise worldwide.
Nawfal Hasan Siam, Umme Halima Mithila, S. Tisha et al.· Health Science Reports· 0 citations
A prioritized roadmap for integrating AI into early clinical xenotransplantation is presented, based on clinical need, data availability, technical readiness, feasibility of clinician‐supervised implementation, and potential impact on graft assessment and safety monitoring.
K. Shirini, Zoe Hahn, J. Ladowski et al.· Xenotransplantation· 0 citations
A structured translational roadmap is proposed that prioritizes biologically predictive design, fit-for-purpose safety assessment, scalable good manufacturing practice production, early regulatory alignment, and clinically meaningful benefit over unnecessary structural complexity.
Yi Li, Rui Luo, Yuxuan Li et al.· Biomedicine & pharmacotherap...· 1 citation
This review highlights how neurotropic viruses co-opt epigenetic pathways to drive neurodegeneration and explores biomarker-driven strategies for personalized interventions in neurodegenerative disorders thus emphasizing potential epigenetic editing tools to restore neuronal homeostasis.
Chaitali Vora, Vaishali Saini, Maxim Shevtsov et al.· Journal of Neurovirology· 0 citations
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Results suggest that MDM2 3’UTR elongation may trigger a non-canonical regulatory mechanism that bypasses the traditional MDM2-p53 interaction, and suggests that APA-mediated gene modulation can induce unforeseen compensatory survival pathways in cancer cells, necessitating further investigation into the broader functi...
Minseo Kim, Celine Yoon, Jaewan Jun et al.· bioRxiv· 0 citations
Two isogenic induced pluripotent stem cell lines carrying homozygous LMNA variants are generated by prime editing of a healthy donor iPSC line, providing a valuable platform for functional characterization and potential clinical reclassification of LMNA VUS.
Lu Liu, David Wu, Amit Manhas et al.· Stem Cell Research· 0 citations
Base editors (BEs) enable efficient A-to-G or C-to-T conversions without double-stranded DNA cleavage, but their editing windows remain difficult to tune, limiting genome engineering flexibility. Here, we engineered CRISPR/Cas12b sgRNA by introducing MS2 hairpins to recruit an MS2-N55K-cytidine deaminase-UGI complex, e...
This review illustrates how HSV-1 has evolved from a naturally neurotropic virus into a versatile biomedical tool, whose therapeutic and research potential emerges from the precise matching of viral properties with disease-specific requirements, delivery contexts, and functional objectives.
Bo Yang, Zhi-Yu Liu, Feng Xiong et al.· Virologica Sinica· 0 citations
The evidence indicates that host genetics will not replace existing control but could reduce reliance on acaricides and chemotherapy, and the evidence indicates that host genetics will not replace existing control but could reduce reliance on acaricides and chemotherapy.
Abdullah Azeem, M. K. Khan, Muhammad Shahid Mahmood et al.· Veterinary parasitology· 0 citations
Endosomal dysfunction and polarity loss are established as drivers of SFTPC-I73T-mediated epithelial injury and mechanisms that may underlie AT2 dysfunction in disease more broadly are highlighted.
Eimear N. Rutherford, Dawei Sun, Kyungtae Lim et al.· American Journal of Respirat...· 0 citations
Evidence on genetic determinants of Hb F and quantified effects of key variants through meta-analysis is synthesized, supporting genotype-guided therapeutic, and genome-editing strategies.
Clinical applicability is limited by issues such off-target effects, PAM sequence restrictions, DNA damage-induced toxicity, and immunological responses to Cas proteins, despite its wide therapeutic potential, but improvements in delivery methods and high-fidelity Cas9 variations are being addressed.
Sanjeyan N., G. G., H. S et al.· International Journal of Bas...· 0 citations
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