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gene editing

1,434 papers

#gene editing Review Open access Aug 2026

Cardiovascular Diseases: Exploring Epidemiology, Pathophysiology, Risk Factors, and Medicinal Plant‐Based Therapies: A Narrative Review

A substantial increase in the global burden of CVDs is demonstrated, with prevalence nearly doubling between 1990 and 2019 and mortality continuing to rise worldwide.

Nawfal Hasan Siam, Umme Halima Mithila, S. Tisha et al. · 0 citations
#gene editing Review Open access Aug 2026

Artificial Intelligence in Xenotransplantation: A Prioritized Roadmap for Early Clinical Translation, Opportunities and Challenges

A prioritized roadmap for integrating AI into early clinical xenotransplantation is presented, based on clinical need, data availability, technical readiness, feasibility of clinician‐supervised implementation, and potential impact on graft assessment and safety monitoring.

K. Shirini, Zoe Hahn, J. Ladowski et al. · 0 citations
#gene editing Review Open access Aug 2026

Nanomaterial-based drug delivery systems: From intelligent delivery to clinical translation and precision nanomedicine.

A structured translational roadmap is proposed that prioritizes biologically predictive design, fit-for-purpose safety assessment, scalable good manufacturing practice production, early regulatory alignment, and clinically meaningful benefit over unnecessary structural complexity.

Yi Li, Rui Luo, Yuxuan Li et al. · 1 citation
#gene editing Review Aug 2026

From viral epigenetic reprogramming to neuroinflammation: Mechanisms driving neurodegeneration

This review highlights how neurotropic viruses co-opt epigenetic pathways to drive neurodegeneration and explores biomarker-driven strategies for personalized interventions in neurodegenerative disorders thus emphasizing potential epigenetic editing tools to restore neuronal homeostasis.

Chaitali Vora, Vaishali Saini, Maxim Shevtsov et al. · 0 citations
#gene editing Open access Aug 2026

Atypical MDM2 p53 Regulation and Chemosensitivity Induced by Proximal PAS Deletion

Results suggest that MDM2 3’UTR elongation may trigger a non-canonical regulatory mechanism that bypasses the traditional MDM2-p53 interaction, and suggests that APA-mediated gene modulation can induce unforeseen compensatory survival pathways in cancer cells, necessitating further investigation into the broader functi...

Minseo Kim, Celine Yoon, Jaewan Jun et al. · 0 citations
#gene editing Open access Aug 2026

Generation of two homozygous iPSC lines carrying variants of uncertain significance in LMNA associated with cardiomyopathy

Two isogenic induced pluripotent stem cell lines carrying homozygous LMNA variants are generated by prime editing of a healthy donor iPSC line, providing a valuable platform for functional characterization and potential clinical reclassification of LMNA VUS.

Lu Liu, David Wu, Amit Manhas et al. · 0 citations
#gene editing Aug 2026

Design of base editing systems with tunable editing hotspots within a defined window through sgRNA engineering.

Base editors (BEs) enable efficient A-to-G or C-to-T conversions without double-stranded DNA cleavage, but their editing windows remain difficult to tune, limiting genome engineering flexibility. Here, we engineered CRISPR/Cas12b sgRNA by introducing MS2 hairpins to recruit an MS2-N55K-cytidine deaminase-UGI complex, e...

Wen-Liang Hao, Lai-Chuang Han, Yao-Kang Wu et al. · 0 citations
#gene editing Review Aug 2026

Engineering HSV-1 for Gene Therapy, Oncolytic Immunotherapy, and Neuroscience.

This review illustrates how HSV-1 has evolved from a naturally neurotropic virus into a versatile biomedical tool, whose therapeutic and research potential emerges from the precise matching of viral properties with disease-specific requirements, delivery contexts, and functional objectives.

Bo Yang, Zhi-Yu Liu, Feng Xiong et al. · 0 citations
#gene editing Review Aug 2026

Can host genetics transform the sustainable control of tropical theileriosis? Insights from the Tick-Theileria interface.

The evidence indicates that host genetics will not replace existing control but could reduce reliance on acaricides and chemotherapy, and the evidence indicates that host genetics will not replace existing control but could reduce reliance on acaricides and chemotherapy.

Abdullah Azeem, M. K. Khan, Muhammad Shahid Mahmood et al. · 0 citations
#gene editing Review Open access Aug 2026

CRISPR gene therapy: a review

Clinical applicability is limited by issues such off-target effects, PAM sequence restrictions, DNA damage-induced toxicity, and immunological responses to Cas proteins, despite its wide therapeutic potential, but improvements in delivery methods and high-fidelity Cas9 variations are being addressed.

Sanjeyan N., G. G., H. S et al. · 0 citations

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Google DeepMind Blog Sep 30, 2026

Introducing SynthID Bio

Proof of concept for watermarking AI-generated proteins while preserving biological function.

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