gene editing

CRISPR/Cas9-Mediated Editing of Bsr-d1 and Pi21 Enhances Blast Resistance in a High-Quality Rice Maintainer Line

Rice (Oryza sativa L.) is a staple food crop worldwide, and improving disease resistance is a core target in rice breeding. In this study, we employed CRISPR/Cas9 genome editing to modify the coding sequence (CDS) of two susceptibility genes, Bsr-d1 and Pi21, in the elite maintainer line Gengxiang B to enhance its blas...

Mitogenome assembly and phylogenetic relationships of Phalaris arundinacea

Comparative analysis of non-synonymous-to-synonymous substitution rate (Ka/Ks) ratios across divergent species revealed that the mitochondrial genome of P. arundinacea underwent stabilizing evolutionary dynamics, characterized by predominant purifying selection with several lineage-specific variations in selective pres...

U.S. consumers’ processing of information about CRISPR-edited pork products

ABSTRACT The commercialization of CRISPR gene-edited pork is advancing rapidly, following the U.S. Food and Drug Administration’s approval of gene-edited pigs resistant to Porcine Reproductive and Respiratory Syndrome (PRRS). As these products move closer to market entry, understanding how consumers seek, process, and...

Exploring the role of CRISPR in advancing space biotechnology: challenges and solutions for human survival beyond earth

This review comprehensively examines the potential applications of CRISPR in space biotechnology, focusing on enhancing astronaut health by targeting genes associated with muscle atrophy, bone loss, radiation resistance, and immune function and the use of CRISPR-engineered microorganisms to support closed-loop life-sup...

Genomics and crop improvement: focus on gene editing and its regulation

The future of crop improvement using GEd technologies lies in the harmonisation or alignment of global policies and regulations to support the trade of agricultural produce and ensure that growers and consumers can benefit from GEd technology.

Zhang Q, Wu Y, Yang J, et al. Viral vector-free generation of orthogonal IL-2–responsive CAR T cells through gene editing of IL-2 and its receptor. Blood Immunol Cell Ther. 2025;1(3):100019.

Osteogenesis Imperfecta from Historical Nosology to Gene-directed Therapy: A Critical Narrative Review of Mechanism, Evidence and Translational Uncertainty

Evaluating critically how historical nosology, molecular pathology and emerging gene-directed interventions relate to one another is evaluated, and to determine which conclusions the accessible evidence can currently sustain are evaluated.

Unravelling DNA: Applying Christian Values to a Genetic Age

The author did an excellent job of explaining these technologies in language that anyone could understand, and showing why they are important and relevant by giving specific examples, and I thought Wild did an excellent job of explaining these technologies in language that anyone could understand.

Epigenetic Regulation of Stress Tolerance and Fruit Quality in Fruit Crops

This study examined the complex roles of epigenetic mechanisms—DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs—in enhancing stress tolerance and regulating fruit quality traits.

A banana susceptibility gene underlying fusarium wilt: validation as a target for disease resistance

It is indicated that banana DMR6 functions as a negative regulator of plant immunity and is closely associated with susceptibility to Fusarium wilt, providing a molecular basis for future functional validation and support DMR6 as a potential target for precise genome editing to develop resistant banana cultivars.

Chromatin-Assisted Targeting Enables Precise DNA Methylation Editing in Plants

SunTag-NOVA robustly installed DNA methylation and repressed transcription at the endogenous FWA, FT and TMM genes with minimal genome-wide off-target consequences, and establishes SunTag-NOVA as a specific epigenome-editing platform for plants.

Noncanonical P gene mRNA editing in Cedar virus generates a U protein that is required for efficient virion production

It is shown that Cedar virus does use mRNA editing, but at an unusual sequence and by inserting either an adenine or a guanine nucleotide and generating a previously unknown protein, termed U, that shares selected features with the V and W proteins of other henipaviruses.