Integrative single-cell and spatial transcriptomics combined with machine learning to discover complement-associated biomarkers in temporal lobe epilepsy with hippocampal sclerosis
This study systematically characterized the complement system in TLE-HS by integrating multi-level omics data, including bulk RNA sequencing, single-cell sequencing, and spatial transcriptomics, and revealed the potential value of complement system gene signatures in clinical diagnosis and personalized treatment of epilepsy.
The mechanisms underlying type 2 diabetes-associated cognitive dysfunction (DACD) remain poorly understood, hindering therapeutic progress. Here, we integrated spatial transcriptomics and single-nucleus RNA sequencing to delineate the spatiotemporal molecular and cellular landscape of DACD in brain tissues from 3- and...
Wei Wu, Yu-Meng Yang, Xi-Xi Zhang et al.· Proceedings of the National...· 0 citations
This dataset defines transcriptomic programs underlying key cellular alterations in TLE, enabling mechanistic dissection of epileptogenesis, and term this microglia population epilepsy-associated microglia (EAM).
Victoria Ho, Ruth Tjondropurnomo, Jennifer Nguyen et al.· iScience· 0 citations
Intrahepatic cholangiocarcinoma (ICC) exhibits substantial cellular heterogeneity and a complex tumor microenvironment (TME), contributing to poor clinical outcomes. Effective prognostic biomarkers and a deeper understanding of the cellular ecosystems associated with high-risk disease remain urgently needed....
Zhen-Chen Zhu, Tao Jiang, Qiu-Hua Liu et al.· Frontiers in Immunology· 0 citations
Glioblastoma, IDH-wildtype, is the most common and malignant adult-type diffuse glioma. It is characterized by extensive heterogeneity and poor prognosis. Recent single-cell RNA-sequencing studies have revealed distinct transcriptional programs that define cellular states such as astrocyte-like, mesenchymal-like, neura...
Koki Ise, Zen-ichi Tanei, Takeru Kuwabara et al.· Pathology international (Pri...· 0 citations
Interindividual heterogeneity in Alzheimer’s disease (AD) remains poorly understood, as disparate single-cell studies leave it unclear whether findings reflect shared architecture or dataset-specific idiosyncrasies. Here, we present panAD, a transcriptomic atlas of >3 million nuclei from 791 individuals across 13 studi...
Negin Rahimzadeh, S. Morabito, S. Khullar et al.· bioRxiv· 0 citations
BACKGROUND
Traumatic brain injury (TBI) triggers microglial activation and disrupts the inflammatory microenvironment in the hippocampus, which are key contributors to neuroinflammation and subsequent secondary brain damage. Nevertheless, the cellular heterogeneity of microglia, their pro-inflammatory activation mechan...
Wen-Bin Dong, Yi-Nuo Jia, Rui-Lin Wang et al.· Brain Research· 0 citations
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