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Author

Y. Shan

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Review Open access Sep 2026

Focal Cortical Dysplasia Type II: Somatic Mutations, Molecular Mechanisms, and Integrative Multi‐Omics Framework

FCD II should be considered a mosaic developmental disorder involving both cell‐autonomous and non‐cell‐autonomous mechanisms and integrating somatic variant detection with cellular, spatial, electrophysiological, and surgical outcomes from matched patient tissue may enable biologically meaningful stratification and su...

Ze-Sheng Li, Yi-He Wang, Jian-Wei Shi et al. · 0 citations
Jul 2026

Integrative single-cell and spatial transcriptomics combined with machine learning to discover complement-associated biomarkers in temporal lobe epilepsy with hippocampal sclerosis

This study systematically characterized the complement system in TLE-HS by integrating multi-level omics data, including bulk RNA sequencing, single-cell sequencing, and spatial transcriptomics, and revealed the potential value of complement system gene signatures in clinical diagnosis and personalized treatment of epi...

Ze-Sheng Li, Jian-Wei Shi, Yan-Feng Yang et al. · 0 citations
Jul 2026

Multilayer Validation Reveals a Glia-Associated Secretome Signature in Temporal Lobe Epilepsy

Multilevel evidence from animal models and clinical CSF samples indicates that microglial activation and glia-related molecular alterations are associated with TLE progression, and related secreted proteins may provide candidate biomarkers for future translational investigation.

Yang Dai, Ze-Sheng Li, Quan-Lei Liu et al. · 0 citations

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