FCD II should be considered a mosaic developmental disorder involving both cell‐autonomous and non‐cell‐autonomous mechanisms and integrating somatic variant detection with cellular, spatial, electrophysiological, and surgical outcomes from matched patient tissue may enable biologically meaningful stratification and su...
Ze-Sheng Li, Yi-He Wang, Jian-Wei Shi et al.· CNS Neuroscience & Therapeut...· 0 citations
This study systematically characterized the complement system in TLE-HS by integrating multi-level omics data, including bulk RNA sequencing, single-cell sequencing, and spatial transcriptomics, and revealed the potential value of complement system gene signatures in clinical diagnosis and personalized treatment of epi...
Ze-Sheng Li, Jian-Wei Shi, Yan-Feng Yang et al.· Functional & Integrative Gen...· 0 citations
Multilevel evidence from animal models and clinical CSF samples indicates that microglial activation and glia-related molecular alterations are associated with TLE progression, and related secreted proteins may provide candidate biomarkers for future translational investigation.
Yang Dai, Ze-Sheng Li, Quan-Lei Liu et al.· Journal of Molecular Neurosc...· 0 citations
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