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Author

Guoguang Zhao

2 papers indexed here

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Jul 2026

Integrative single-cell and spatial transcriptomics combined with machine learning to discover complement-associated biomarkers in temporal lobe epilepsy with hippocampal sclerosis

This study systematically characterized the complement system in TLE-HS by integrating multi-level omics data, including bulk RNA sequencing, single-cell sequencing, and spatial transcriptomics, and revealed the potential value of complement system gene signatures in clinical diagnosis and personalized treatment of epi...

Ze-Sheng Li, Jian-Wei Shi, Yan-Feng Yang et al. · 0 citations
Jul 2026

Multilayer Validation Reveals a Glia-Associated Secretome Signature in Temporal Lobe Epilepsy

Multilevel evidence from animal models and clinical CSF samples indicates that microglial activation and glia-related molecular alterations are associated with TLE progression, and related secreted proteins may provide candidate biomarkers for future translational investigation.

Yang Dai, Ze-Sheng Li, Quan-Lei Liu et al. · 0 citations

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