Unveiling the power of TIIC: A prognostic tool for esophageal adenocarcinoma

Abstract

Highlights • A novel TIIC signature score predicts esophageal adenocarcinoma prognosis with high accuracy.• Integrating 20 machine learning algorithms establishes a reliable, data-driven prognostic model.• High TIIC scores correlate with poor survival outcomes and enhanced tumor genomic instability.• TIIC signature score offers insights into immune response and immunotherapy potential for EAC patients.