Pan-cancer screening and integrative multi-omics and deep learning reveal the prognostic significance of an IBD-CRC shared host–microbe signature in bladder urothelial carcinoma

Abstract

Highlights • An IBD-CRC shared host–microbe signature predicts prognosis in BLCA.• The LASSO risk score is associated with basal/squamous features and immune exhaustion.• Single-cell and spatial analyses reveal malignant cell heterogeneity linked to signature activity.• WSI-based attention MIL predicts molecular risk status from routine H&E slides.• RF-SHAP and SNV/CNV analyses identify risk score-associated molecular features.