Aug 2026· Neuromolecular medicine· Vol 28· 0 citations· 121 references
Medicine
TL;DR
It is proposed that a systems-level approach can be taken where PD is understood as a disease characterized by the imbalance in proteostasis, and potential treatment modalities include small molecules targeting lysosome function, CMA enhancers, gene therapy, and antibodies against extracellular α-synuclein.
This review focuses on translational insights linking α-syn pathology to dysregulated stress-response and protein quality-control pathways, intending to identify potential targets for disease-modifying intervention.
Swaprakash Paul, Abhideep Roy, Pallab Bhattacharya et al.· Current Pharmacology Reports· 0 citations
Neurodegenerative diseases, including Huntington's disease, Parkinson's disease, Alzheimer's disease, and Amyotrophic Lateral Sclerosis (ALS), are characterized by progressive neuronal dysfunction and loss, often accompanied by toxic protein aggregation and chronic neuroinflammation. Increasing evidence indicates that...
Anushka Verma, S. Kushwaha, Neelottama Kushwaha et al.· CNS and Neurological Disorde...· 0 citations
Abstract Ageing is a primary risk factor for neurodegenerative disorders, including Parkinson's disease (PD). As individuals age, their cells become less efficient in maintaining protein homeostasis, leading to an increased likelihood of protein misfolding and aggregation. A hallmark of PD and other synucleinopathies i...
Suzanne Couzijn, Anna P. Ainslie, Alejandro Herron-Bedoya et al.· Philosophical transactions o...· 0 citations
This network is interconnected, and understanding it is crucial in the creation of therapies that attempt to restore proteostasis, inhibit inflammation, and increase neurotrophic signalling to delay or prevent PD progression.
Riddhi Upadhyay, Murugan Sevanan· Advances in Immunology· 0 citations
Abstract Clinically distinct neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), share in common progressive neuronal dysfunction and cell death associated with the accumulation of misfolded proteins. Central to these processes are the cellul...
James F. Morley· Philosophical transactions o...· 0 citations
Overall, postbiotics may represent a promising therapeutic strategy for targeting neurodegenerative processes in PD, although their safety, efficacy, optimal dosing, and clinical utility require further investigations.
Anjali Kumari, K. Aran· Metabolic brain disease· 0 citations
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