Huma Hameed

Polyplex-Based Nonviral Gene Delivery: Recent Advances in Polymer Design, Mechanisms, and Therapeutic Applications

ABSTRACT Polyplexes are versatile, efficient nonviral vectors for gene-based therapies and offer safer alternatives to conventional viral delivery systems. Delivering nucleic acids, including DNA, RNA, and siRNA, remains challenging because of limited stability, cellular uptake, and intracellular trafficking. Formed th...

Structure-Based Virtual Screening and Computational Evaluation of Putative Mushroom-Associated Natural Compounds as Janus Kinase 1 (JAK1) Inhibitors: An In Silico Study.

INTRODUCTION/OBJECTIVE Janus kinase 1 (JAK1) is a key controller and regulator of cytokinemediated immune responses and an effective therapeutic target in autoimmune and inflammatory diseases. In the present study, an in silico workflow was implemented to identify secondary metabolites of mushrooms as prospective JAK1-...

The multifunctional glycosaminoglycan: mechanistic insights into chondroitin sulfate driven tissue repair

This review synthesizes emerging insights into the molecular mechanisms of CS and elucidates how these translate into clinical and biomedical applications for wound management by bridging fundamental biology with translational approaches.

Rebalancing α-Synuclein Clearance: Novel Therapeutic Frontiers in Parkinson’s Disease

Formulation, evaluation and characterization of fexofenadine IR and paracetamol SR multiparticulate drug delivery system.

The research effectively demonstrated that preparing a single-unit dosage form of paracetamol and fexofenadine is a safe, simple and promising technique for SR of Paracetamol, thereby increasing patient compliance by reducing the dosage frequency.

Eudragit S100-coated microbeads of thiolated chitosan/casein for pH-responsive colon-targeted delivery of 6-mercaptopurine

Overall, the Eu-S100@TCh/CS microbead system represents a rationally designed colon-targeted delivery platform with potential to improve local therapeutic efficacy and reduce systemic toxicity.