Decoding next-generation heavy metal bioremediation via species-specific Earthworm and its gut microbiome interactions: insights from molecular responses, multi-omics, synthetic biology, and artificial intelligence

Fungi to the rescue: recent advances, mechanistic insights and omics-based perspectives in heavy metal mycoremediation

Bacterial Degradation of Persistent Organic Pollutants: From Molecular Mechanisms to Synthetic Biology.

Persistent organic pollutants (POPs) are among the most recalcitrant environmental contaminants due to their chemical stability, hydrophobicity, toxicity, and capacity for long-range transport, yet mechanistic understanding remains fragmented across molecular, cellular, and systems scales, hindering integrated bioremed...

Multi-omics insights into bacterial and fungal bioremediation of Potentially Toxic Elements (PTEs): a critical overview of their applications

This review examines the major advances of the last decade in the application of genomics, transcriptomics, proteomics, and metabolomics and their integration, to investigate molecular mechanisms of microbial adaptation to PTE contamination, supporting the selection of suitable microorganisms or microbial communities a...

Engineering Plant–Microbiome Interaction Networks for Predictive Soil Bioremediation Under the Stress–Stability Paradox

Soil pollution poses a profound threat to ecosystem and human health. This review proposes a novel framework centered on engineering biological interaction networks for efficient and sustainable soil decontamination, moving beyond the traditional single‐species paradigm. We dissect the architecture and dynamics of key...

A synthetic microbiome drives a multi-omics response to remediate 1,4-dithiane-contaminated soil and simultaneously suppresses antibiotic resistance genes.

1,4-Dithiane, a degradation product of abandoned Japanese chemical weapons, is a persistent organic pollutant with ecological risks. A synthetic microbiome (SM) was constructed through pollution stress screening and ratio optimization, consisting of Shinella sp., Alcaligenes faecalis, Sphingomonas sp., and Stenotrophom...

Engineering cyanobacterial resilience for cadmium bioremediation: linking Cd speciation, cellular detoxification, and synthetic biology

Cadmium (Cd) is a persistent, non-essential toxic metal that threatens aquatic and terrestrial ecosystems, agricultural productivity, and food safety. Cyanobacteria offer a promising platform for Cd bioremediation by combining photoautotrophic growth with extracellular metal binding, membrane transport, intracellular s...