Skip to content
#protein folding Open access

Title: Dynamic Topology Optimization with Adaptive Recurrence

Sep 2026 · Zenodo (CERN European Organization for Nuclear Research)
Topology Optimization in Engineering

Abstract

Dynamic Topology Optimization (DTO) is a powerful tool for designing complex systems, such as neural networks and protein folding, by iteratively refining the topology to meet specific requirements. Traditional DTO methods often rely on static parameters, limiting the system's adaptability and potentially hindering the creation of robust and flexible designs. This paper introduces a novel algorithm, Dynamic Topology Optimization with Adaptive Recurrence, that moves beyond static parameter tuning by incorporating a "recurrence kernel" – a dynamically updating metric that assesses the system's internal dynamics and iteratively refines the topology to achieve a desired property. We demonstrate the effectiveness of this approach through the application of the algorithm to a series of challenging, complex systems, showcasing improved optimization speed and the potential for generating inherently robust and flexible designs. The core mechanism involves the continuous assessment of system health through the recurrence kernel, allowing for iterative refinement based on real-time feedback. This shift from static parameters to dynamic feedback represents a significant advancement in the field of topology optimization, paving the way for more adaptable and efficient design processes.

View source

Similar papers

#computer vision Review Open access May 2015

A survey study on major technical barriers affecting the decision to adopt cloud services

The comparison of adopter and non-adopter sample reveals three potential adoption inhibitor, security, data privacy, and portability, which underlines the importance of the technical and security perspectives for research investigating the adoption of technology.

Nattakarn Phaphoom, Xiaofeng Wang, S. Samuel et al. · 111 citations · ⚡8
#computer vision Open access Feb 2018

Lean Internal Startups for Software Product Innovation in Large Companies: Enablers and Inhibitors

This study investigates how Lean internal startup facilitates software product innovation in large companies and identifies its enablers and inhibitors, and shows the potential of the method-in-action framework to investigate the Lean startup approach in non-startup context.

Henry Edison, Nina M. Smørsgård, Xiaofeng Wang et al. · 78 citations · ⚡6
#computer vision Book Open access Jul 2015

Understanding the affect of developers: theoretical background and guidelines for psychoempirical software engineering

This paper highlights the challenges to conduct proper affect-related studies with psychology, provides a comprehensive literature review in affect theory, and proposes guidelines for conducting psychoempirical software engineering.

D. Graziotin, Xiaofeng Wang, P. Abrahamsson · 56 citations · ⚡4
#machine learning Open access May 2017

What Influences the Speed of Prototyping? An Empirical Investigation of Twenty Software Startups

This study conducts a multiple case study on twenty European software startups and proposes a prototype-centric learning model in early stage software startups, and identifies factors that occur as barriers but also facilitators for prototyping in earlystage software startups.

Anh Nguyen-Duc, Xiaofeng Wang, P. Abrahamsson · 44 citations · ⚡5
#protein folding Open access Sep 2026

Programmable design of functional proteins from natural language

Pinal, a 16-billion-parameter foundation model that produces protein candidates from natural-language functional descriptions, supports natural language as a high-level interface for candidate generation in protein design, enabling programmable exploration with reduced reliance on manually specified structural or sequence constraints.

Fengyuan Dai, Shiyang You, Yudian Zhu et al. · 31 citations · ⚡3

Related blog posts

MIT News · Artificial Intelligence Aug 27, 2026

Looking beyond natural sequences

A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.

Google DeepMind Blog Nov 25, 2025

AlphaFold: Five years of impact

Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.