Aug 2026· Clinical and Experimental Metastasis· Vol 43· 0 citations· 71 references
Medicine
TL;DR
Thrombospondin-2 has emerged as a pivotal yet paradoxical regulator within the breast cancer tumor microenvironment and is a key architect of an immunosuppressive “cold” TME, so therapeutic inhibition of THBS2 presents a promising integrative “cold-to-hot” conversion strategy.
The tumor microenvironment is a complex ecosystem where the extracellular matrix serves as a dynamic signaling hub and regulates tumorigenesis. Thrombospondin-2 (THBS2), a matricellular extracellular matrix protein, has traditionally been regarded as an inhibitor of angiogenesis. However, emerging evidence reveals a pl...
Hetal Abhay Shah, Maushmi S. Kumar· Frontiers in Pharmacology· 0 citations
This review focuses specifically on BC and integrates pathogenic mechanism analysis with inter-subtype comparisons across BC subtypes and existing SASP-targeted therapeutic strategies are discussed, with the aim of providing novel insights into the potential role of SASP in BC treatment.
Xian-Neng Gao, Yun-Long Zhang, Yue Sun et al.· Frontiers in Oncology· 0 citations
Glioblastoma (GBM) remains one of the most lethal cancers, with recurrence in nearly all patients despite standard therapy. However, the biological mechanisms governing recurrence remain incompletely understood. Increasing evidence suggests that recurrence is driven not only by tumor-intrinsic resistance, but also by d...
Jian-Yu Lu, Rou-Xi Song, Wei Gao et al.· Biochimica et biophysica act...· 0 citations
This review systematically synthesizes advances in the pivotal, context-dependent roles of BTG2 in non-tumor pathologies, including fibrotic, neurological, cardiovascular, inflammatory, metabolic and other systemic diseases.
Shu-Ling Li, Xiao-Mei Liu, Zheng Zhang et al.· International Journal of Mol...· 0 citations
This review systematically synthesizes the mechanistic roles of USP2 across various cancers, highlighting its function as a double-edged sword, and comprehensively evaluates the landscape of emerging USP2 inhibitors.
Peng Hao, Jiale Wan, Zhangyu Guo et al.· Biochimica et biophysica act...· 0 citations
The establishment of an immunosuppressive tumor microenvironment (TME) represents a central mechanism underlying the failure of conventional therapies and resistance to immunotherapy in hepatocellular carcinoma (HCC). Tumor-associated macrophages (TAMs), as the most abundant immune cell population within this microenvi...
Peng Ma, Xin-Da Lu, Jian-Li Han et al.· Frontiers in Pharmacology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
