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Shujie Yang

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Review Aug 2026

THBS2: the key hub linking breast cancer stroma, immunity, and therapeutic response

Thrombospondin-2 has emerged as a pivotal yet paradoxical regulator within the breast cancer tumor microenvironment and is a key architect of an immunosuppressive “cold” TME, so therapeutic inhibition of THBS2 presents a promising integrative “cold-to-hot” conversion strategy.

Xi Wan, Xin-Chen Zhao, Yao Lin et al. · 0 citations

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