Genome-Wide Association Studies and Deep-Learning Functional Annotation of Opioid Use Disorder across Three Ancestries in the All of Us Research Program

Common Threads: Uncovering Convergent Pathways for Cannabis Use Disorder Across Diverse Populations

Association of the Schizophrenia Risk Locus rs10866912 with Cerebral Volumes, Diet, and Psychosis in the UK Biobank

Background: Leading schizophrenia GWAS signals require evaluation of their pathological significance across diverse ancestries. rs10866912 reached genome-wide significance in our Indian ancestry GWAS of schizophrenia; its risk allele reduces expression of NAPRT, the rate-limiting enzyme in the brain’s principal NAD+-sy...

Brain imaging-derived phenotypes influence risk of bipolar disorder: comprehensive exposome-wide association and wide-angled genetic analyses

An atlas of brain IDPs associated with bipolar disorder is established, by integrating epidemiological and genetic evidence, and candidate IDPs that were consistently associated with BD are highlighted across complementary analyses.

Genotype-by-regional ancestry proxy interactions at 8q24 reveal association heterogeneity in prostate cancer risk.

The 8q24 region is a major prostate cancer susceptibility locus, but variant effects may differ across ancestry-associated haplotype contexts. We analyzed whole genome sequencing and electronic health record data from 166,155 male participants in the NIH All of Us Research Program (10,166 cases and 155,989 controls). A...

Suggestive genome-wide associations with inflammatory biomarkers in an admixed population, including a missense variant in the OR6K6 olfactory receptor gene associated with MCP-1

New SNPs linked to inflammatory biomarkers in a highly admixed Brazilian population are identified, including a missense variant in an olfactory receptor gene linked to MCP-1, which may be biologically important for inflammation and could affect the risk of cardiometabolic diseases.

A multi-ancestry genome-wide association study of dry eye disease and systemic comorbidities

The observed genetic correlations are consistent with shared genetic liability between DED and chronic pain, autoimmune, and psychiatric traits, but do not establish causal direction.