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This study identifies DDX6 as a novel OUD risk locus, replicates associations with OPRM1 and FURIN, and highlights biologically plausible ancestry-specific signals in AFR and AMR populations.
The potential of single-cell miRNA profiling to contribute to precision medicine and therapeutic development is outlined, including its possible use in biomarker discovery, monitoring tumor heterogeneity, and informing personalized treatment strategies.
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