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Cross-Species Efficacy of Combinatorial Gene Therapy for Osteoarthritis and Correction of Neuro-Inflammatory Pain Mechanisms

E. Secor Jun Wang Zelong Dou Jiansen Yan Camilla F. Majano Matthew J Woodman Oscar E. Ruiz Joud Al Azaat Duncan Crosby Racel Cela S. Pownder J. Engiles D. Palmer Ming-Ming Jiang Carolina Leynes Ismail Yaman M. Jeong Gerhard Sponder Stanislav Plutziki L. Yuva S. Veeraragavan Russell S. Ray Joshua D. Wythe Benjamin R. Arenkiel Rui Chen K. Worley Philip Ng Masataka Suzuki K. Guse Yangjin Bae Nele A. Haelterman H. Reesink Brendan H. Lee

Jul 2026 · bioRxiv · 0 citations

Biology Medicine

TL;DR

A single intra-articular injection of a combinatorial gene therapy slows OA progression and reduces pain in small and large animal models, and identifies neuroinflammatory signatures for correction of disease progression and pain.

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