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Author

Carolina Leynes

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Open access Oct 2026

Multi-omic profiling reveals impaired luteal resolution and CHK2-regulated inflammation in ovarian aging

The ovary ages earlier than most other organs, but the molecular mechanisms that drive this decline remain unclear. To gain more insight into this process, we profiled ovaries from young and reproductively aged mice after synchronized ovulation and found that aging was marked by the accumulation of luteal cells with in...

Liu-Bin Yang, Zhong-Wei Sun, Xin-Long Luo et al. · 0 citations
Open access Jul 2026

Cross-Species Efficacy of Combinatorial Gene Therapy for Osteoarthritis and Correction of Neuro-Inflammatory Pain Mechanisms

A single intra-articular injection of a combinatorial gene therapy slows OA progression and reduces pain in small and large animal models, and identifies neuroinflammatory signatures for correction of disease progression and pain.

E. Secor, Jun Wang, Zelong Dou et al. · 0 citations

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