The results provide an epitope-level explanation for the sustained diagnostic reliability of the mAb N179-based assay against emerging variants, clarify the molecular basis for its lack of cross-reactivity, and may inform the rational design of SARS-CoV-2 diagnostics targeting conserved, mutation-resistant epitopes.
This motif may serve as a reference for the selection and evaluation of diagnostic antibodies targeting conserved regions of the SARS-CoV-2 N protein and show that this sequence is conserved among the representative SARS-CoV-2 lineages analyzed.
Zhoujun Su, Junhao Guo, Ning Li et al.· Viruses· 0 citations
This study identifies a novel, highly conserved with conservative substitutions linear B-cell epitope on the RABV glycoprotein, providing a precise molecular target for the rational design of next-generation epitope-based vaccines and specific diagnostic tools.
Yu-Mei Chen, Xiao-Hui Zhang, Yan-Hua Qi et al.· Medical Microbiology and Imm...· 0 citations
Avian reovirus (ARV) causes of multisystemic, immunosuppressive infectious diseases in poultry. Among them, the σC protein, a structural component of the outer capsid encoded by the S1 genome segment, plays a crucial role in viral attachment and cellular entry. In this study, we expressed the σC protein derived from th...
The high mutation rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) may alter viral protein structures and reduce the effectiveness of vaccines that primarily target the spike (S) protein. The nucleocapsid (N) protein is highly conserved and immunogenic, making it a promising alternative antigen for...
Wenny Maylina Mulyo Tjahyani, Surya Rosa Putra, Devy Maulidya Cahyani et al.· EPJ Web of Conferences· 0 citations
A novel linear B-cell epitope, 97LGDGDEIR104, is identified within the flexible N-terminal region of gB, which was critical for antibody binding, revealing a new antigenic site on VZV gB.
Yu-Mei Chen, Meng-Ru Yang, Hong-Liang Liu et al.· Archives of Microbiology· 0 citations
Duck hepatitis A virus type 3 (DHAV-3) continues to circulate, threatening the health of duck flocks and highlighting the urgent need for novel antibody-based interventions. In this study, we systematically profiled the DHAV-3-specific B cell immune repertoire in VP1-immunized mice, using high-throughput single-cell RN...
Sai-Sai Zhao, Fang-Bo Wu, Rui-Qi Shi et al.· International Journal of Bio...· 0 citations
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