Abstract This study developed an ultrasound-assisted deep eutectic solvent (DES) platform for the green recovery of quercetin from onion peels. It elucidated the extraction mechanism through process optimization and molecular simulations. Among the screened systems, betaine-malonic acid (Bet-MLN) exhibited the strongest synergistic extraction capability. Single-factor tests and Box–Behnken design optimized the conditions at extraction temperature 50 °C, extraction time 40 min, DES water content 34.11%, liquid–solid ratio 26.98:1, and ultrasonic power 376.26 W, yielding 21.83 mg/g quercetin, 30.27 mg RE/g flavonoids, and 77.33 mg GAE/g polyphenols, consistent with model predictions. LC-MS identified quercetin diglucoside, monoglucoside, and aglycone, with monoglucoside predominating. C18 reversed-phase solid-phase extraction enabled stepwise purification and enrichment and markedly enhanced DPPH and ABTS scavenging. Quantum chemistry and molecular dynamics simulations confirmed that hydrogen bonding, electrostatic complementarity, van der Waals synergy, and diffusion collectively drove flavonoid/polyphenol desorption, solvation, and migration, thereby supporting the valorization of agricultural by-products.
The results are packaged in the Greenfield Startup Model (GSM), which explains the priority of startups to release the product as quickly as possible, and the need to shorten time-to-market, by speeding up the development through low-precision engineering activities.
Carmine Giardino, Nicolò Paternoster, M. Unterkalmsteiner et al.· IEEE Transactions on Softwar...· 178 citations· ⚡14
Software startup companies develop innovative, software-intensive products within limited timeframes and with few resources, searching for sustainable and scalable business models.
M. Unterkalmsteiner, P. Abrahamsson, Xiaofeng Wang et al.· e-Informatica Software Engin...· 157 citations· ⚡17
This study conducts a case survey study based on the secondary data of the major pivots happened in 49 software startups, and demonstrates that customer need pivot is the most common among all pivot types.
Sohaib Shahid Bajwa, Xiaofeng Wang, Anh Nguyen-Duc et al.· Empirical Software Engineeri...· 127 citations· ⚡15
The comparison of adopter and non-adopter sample reveals three potential adoption inhibitor, security, data privacy, and portability, which underlines the importance of the technical and security perspectives for research investigating the adoption of technology.
Nattakarn Phaphoom, Xiaofeng Wang, S. Samuel et al.· Journal of Systems and Softw...· 111 citations· ⚡8
This study investigates how Lean internal startup facilitates software product innovation in large companies and identifies its enablers and inhibitors, and shows the potential of the method-in-action framework to investigate the Lean startup approach in non-startup context.
Henry Edison, Nina M. Smørsgård, Xiaofeng Wang et al.· Journal of Systems and Softw...· 78 citations· ⚡6
The application of agile software methods and more recently the integration of Lean practices contribute to the trend of continuous improvement in the software industry. One such area warranting proper empirical evidence is a project’s operational efficiency when using the Kanban method. This short paper takes a new angle and explores waste in the Kanban-driven software development project context. A preliminary research model is presented for helping the consequent replication of the study. The results from the empirical analysis suggest Kanban can be an effective method in visualizing and organizing the current work, but does not prevent waste from creeping in, although the overall project outcome may be successful.
Marko Ikonen, Petri Kettunen, Nilay V. Oza et al.· EUROMICRO Conference on Soft...· 67 citations· ⚡9
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