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Aurone analog LYK01 exerts oxidative stress-dependent antiproliferation, G2/M arrest, apoptosis, and DNA damage of oral cancer cells involving MAPK modulation

Yan-Ning Chen Chia-Hung Yen C. Yen AmmadAhmad Farooqi M. Chang Tsu-Ming Chien Jen-Yang Tang Hsueh-Wei Chang
Jul 2026 · Molecular and Cellular Biochemistry · Vol 481, pp. 4363 - 4379 · 1 citation · 82 references
Medicine

TL;DR

In conclusion, LYK01 exhibits preferential antiproliferative effects in oral cancer cells —mediated by oxidative stress and MAPK-associated pathways—while exhibiting limited cytotoxicity toward normal cells.

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