Jul 2026
Aurone analog LYK01 exerts oxidative stress-dependent antiproliferation, G2/M arrest, apoptosis, and DNA damage of oral cancer cells involving MAPK modulation
In conclusion, LYK01 exhibits preferential antiproliferative effects in oral cancer cells —mediated by oxidative stress and MAPK-associated pathways—while exhibiting limited cytotoxicity toward normal cells.
Yan-Ning Chen, Chia-Hung Yen, C. Yen et al.
· Molecular and Cellular Bioch... · 1 citation