Good neighbors make lasting memory

Cytotoxic CD4+ T cells support age-associated myelopoiesis

It is discovered that cytotoxic CD4+ T cells foster this process via the CCL5–CCR5 axis and it is found that the clinically approved CCR5 antagonist maraviroc can rebalance immunity in aged mice.

Old dog, new tricks: Astrocytes use the CD40 pathway to propagate neuroinflammation.

In addition to myeloid antigen-presenting cells (APCs), CD40 also induces APC potential in astrocytes during neuroinflammation.

Epithelial antigen presentation shapes barrier memory

CD8+ T cells kill tumors by proxy

Malaria durably disrupts macrophage-to-macrophage crosstalk in the spleen.

Blood-stage malaria transiently depletes and remodels splenic macrophages, but how distinct subsets recover remains unclear. A recent report by Mauel et al. shows that a yolk sac-derived CD163high red pulp macrophage subset is selectively and durably lost after malaria, disrupting a growth differentiation factor 15-dep...

A tolerogenic function for gut TFH cells