Malaria durably disrupts macrophage-to-macrophage crosstalk in the spleen.

Abstract

Blood-stage malaria transiently depletes and remodels splenic macrophages, but how distinct subsets recover remains unclear. A recent report by Mauel et al. shows that a yolk sac-derived CD163high red pulp macrophage subset is selectively and durably lost after malaria, disrupting a growth differentiation factor 15-dependent circuit that supports marginal metallophilic macrophages.