Results suggest that Adgrd1 plays a key role in maintaining hippocampal resilience and regulating motivational behaviors through integrated molecular and circuit-level mechanisms.
It is demonstrated that transregional metaplasticity, as driven by prior activity in the stratum oriens (SO) in a way that inhibits subsequent LTP in wild-type mice, is occluded in PS19 mice, suggesting that the tauopathic hippocampus exists in a “metaplastic” state, which inhibits future LTP.
Shruthi Sateesh, B. Logan, O. Jones et al.· bioRxiv· 0 citations
These findings identify ankyrin-G as a molecular bridge between excitatory neuronal activity, synaptic structure, and myelin-associated protein expression, revealing a pathway by which ANK3 variants may contribute to neuropsychiatric disease.
Sehyoun Yoon, Marc Dos Santos, Natalia Khalatyan et al.· Proceedings of the National...· 0 citations
It is demonstrated that Ddit4 overexpression specifically in neurons is sufficient to reduce spine density in the PFC, impair temporal order memory, and induce transcriptional changes associated with stress and depression.
Alexander M. Kuhn, Kelly E. Bosis, Madeline M. Mairose et al.· eNeuro· 0 citations
These findings identify ANO2 as a potential modulator of dopamine-related signaling and inhibitory behavioral control, expanding current understanding of calcium-activated chloride channel function in neural circuits relevant to behavioral domains implicated in neuropsychiatric disorders.
E. Cho, Jooeun Bae, J. Song et al.· Neuropsychopharmacology· 0 citations
This study indicates that KIF2C may regulate microtubule dynamics to control deep-layer cortical neuron number and organization and modulate neuronal projections and signaling pathways and provides a foundation for understanding the role of KIF2C in neural development.
It is shown that Nav1.3, a subtype normally confined to early development, shows aberrantly increased expression in the dentate gyrus (DG)-CA3 circuit in early-stage 5xFAD mice, which is identified as a driver of early hippocampal network dysfunction in AD.