Aug 2026· Neuropsychopharmacology· 0 citations· 34 references
Medicine
TL;DR
These findings identify ANO2 as a potential modulator of dopamine-related signaling and inhibitory behavioral control, expanding current understanding of calcium-activated chloride channel function in neural circuits relevant to behavioral domains implicated in neuropsychiatric disorders.
Results suggest that Adgrd1 plays a key role in maintaining hippocampal resilience and regulating motivational behaviors through integrated molecular and circuit-level mechanisms.
Inés Martínez-Soria, Pol Picón-Pagès, Anna P. Pérez-González et al.· bioRxiv· 0 citations
It is suggested that Neu1-mediated PSA degradation may modulate dopamine D3 receptor-dependent nicotine sensitivity and contribute to reduced PSA levels and altered dopamine D3 receptor-related signaling, thereby influencing the threshold for nicotine-induced neural and behavioral activation.
Sumomo Tsuji, Haruka Ego, Ryota Shimizu et al.· Fish Physiology & Biochemist...· 0 citations
These findings suggest that MRs in GABAergic neurons normally function as critical constraints on excitatory synaptic plasticity during high-stress states, underscoring that adaptive stress responses rely on a finely tuned, cell-type-specific balance of corticosteroid signaling within limbic microcircuits.
Huanqing Yang, V. Kovářová, Alena O. Godunova et al.· Neurobiology of Stress· 0 citations
The results suggest that β-catenin deficiency in forebrain excitatory neurons leads to fear conditioning impairment, which could be contributed by the diminished excitatory synaptic transmission in PFC resulting from disrupted synaptic gene expression.
Luis Gustavo Hernandez Carballo, Rachel Senek, Ksenia Novototskaya-Vlasova et al.· Brain Communications· 0 citations
It is demonstrated that morphine exposure selectively activates GSDMD-mediated pyroptotic signaling in the dorsal hippocampus (dHip), identifying neuronal pyroptosis as a previously unrecognized mechanism associated with morphine-associated reward memory and position GSDMD as a potential therapeutic target that warrant...
Dongyu Yu, Xi-Xi Yang, Xiao-Yu Yang et al.· Neuropharmacology· 0 citations
It is demonstrated that Ddit4 overexpression specifically in neurons is sufficient to reduce spine density in the PFC, impair temporal order memory, and induce transcriptional changes associated with stress and depression.
Alexander M. Kuhn, Kelly E. Bosis, Madeline M. Mairose et al.· eNeuro· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
