Synucleinopathies are a group of neurodegenerative disorders characterized by the misfolding, aggregation, and accumulation of α-synuclein (α-syn) into oligomeric assemblies and amyloid inclusions. Alongside neurons, glial cells can internalize pathological α-syn and play a major role in its degradation. Despite...
Lea Šustić, Elena de Cecco, Sandesh Neupane et al.· Cell Communication and Signa...· 0 citations
These results establish a mechanistic link between peptide-induced stabilization of PrPc and inhibition of prion propagation and provide a generalizable framework for designing conformational stabilizers of aggregation-prone proteins.
Elpiniki Paspali, C. Morales, Daria De Raffele et al.· bioRxiv· 0 citations
Results suggest that Adgrd1 plays a key role in maintaining hippocampal resilience and regulating motivational behaviors through integrated molecular and circuit-level mechanisms.
Inés Martínez-Soria, Pol Picón-Pagès, Anna P. Pérez-González et al.· bioRxiv· 0 citations
Lipofection- and lentivirus-mediated protocols for CRISPR-Cas9 delivery in mouse-passaged primary human hepatocytes (mpPHH) are reported, a system that enables PHH expansion in liver-humanized mice and enables scalable genetic manipulation of mpPHH, opening new avenues for HBV research and liver disease modeling.
Ansgar F. Stenzel, Antonis Athanasiadis, Georgios Dangas et al.· bioRxiv· 0 citations
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