Oct 2026· BIOspektrum· Vol 32, pp. 632 - 635· 0 citations· 12 references
TL;DR
CARMEN is introduced, a polycistronic fluorescence-based biosensor system that enables simultaneous, high-resolution monitoring of Ca 2+ signals in distinct subcellular compartments within the same living cell, supporting future high-content imaging and drug-screening applications.
Abstract
Calcium (Ca
2+
) signals are key mediators of cellular information processing and regulate numerous physiological processes. Their dynamic and compartmentalised nature is linked to cellular function and disease. Here, we introduce CARMEN, a polycistronic fluorescence-based biosensor system that enables simultaneous, high-resolution monitoring of Ca
2+
signals in distinct subcellular compartments within the same living cell, supporting future high-content imaging and drug-screening applications.
An extensive analysis of the physical principles of blood composition detection technologies based on optical biosensors and their role in modern medical diagnostics contributes to the development of advanced diagnostic systems and improvement of clinical monitoring efficiency.
Super-resolution microscopy is applied on Ca V 1.3 channels in stem-cell derived atrial myocytes to study cluster architectures and dynamics, finding that these channels are mobile inside membrane domains, being loosely clustered in contrast to previous models of dense channel packing.
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