Olive leaf extract attenuates acrylamide-induced reproductive toxicity through reduced oxidative DNA damage and apoptosis associated with 8-OHdG and Caspase-3 in rats
Aug 2026· Journal of Molecular Histology· Vol 57· 0 citations· 63 references
Medicine
TL;DR
Investigating the protective effects of OLE against ACR-induced reproductive toxicity in male and female rats indicates that OLE exerts a significant cytoprotective effect through its antioxidant and anti-apoptotic properties, with the extent of protection varying across tissue types.
Overall, the findings indicate that Que mitigates PdCl₂-induced testicular injury, and that this protection may be associated with antioxidant, anti-inflammatory, anti-apoptotic, ER stress-related, and Nrf2/HO-1-associated responses rather than direct proof of pathway activation.
Acrylamide (Acr) is a widely encountered environmental and dietary toxicant known to induce oxidative stress and disrupt male reproductive function. Leydig cells, due to their high metabolic activity and mitochondrial dependence, are particularly vulnerable to redox imbalance. N-acetylcysteine (Nac), a thiol-containing...
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VOO may mitigate TiO₂-NP-induced hepato-renal toxicity in rats, possibly through antioxidant and anti-inflammatory mechanisms, as suggested by both in-vivo and in silico findings.
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Niosomal hesperidin-rich Citrus peel extract provides superior protection against TIR-induced oxidative and apoptotic injury compared with free hesperidin, likely due to enhanced stability, and support the use of nanocarrier-based delivery systems to improve the therapeutic potential of natural antioxidants in reproduc...
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