Niosomal Hesperidin-Rich Citrus Peel Extract Attenuates Testicular Ischemia–Reperfusion Injury in Rats by Modulating p53- and Caspase-3-Associated Apoptotic Responses

Melika Behdadfar A. Asghari Zohre Eftekhari Seyed Mehdi Ghamsari

Aug 2026 · Journal of Pharmaceutical Innovation · Vol 22 · 0 citations · 28 references

TL;DR

Niosomal hesperidin-rich Citrus peel extract provides superior protection against TIR-induced oxidative and apoptotic injury compared with free hesperidin, likely due to enhanced stability, and support the use of nanocarrier-based delivery systems to improve the therapeutic potential of natural antioxidants in reproductive medicine.

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