Protective Effects of Virgin Olive Oil Against Titanium Dioxide Nanoparticle-Induced Hepato-Renal Toxicity: Evidence from Oxidative Stress Biomarkers and Restoration of Antioxidant Enzyme Activities.
Jul 2026· Biological Trace Element Research· 0 citations· 45 references
Medicine
TL;DR
VOO may mitigate TiO₂-NP-induced hepato-renal toxicity in rats, possibly through antioxidant and anti-inflammatory mechanisms, as suggested by both in-vivo and in silico findings.
Introduction Repeated heating of vegetable oils leads to the generation of toxic oxidation products, which activate systemic oxidative stress and cause multi-organ injuries. This study examined the hepatorenal synergistic protection of Curcumin Nano-Emulsion (CNE) and virgin coconut oil (VCO) against the toxicity of th...
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The results of this study showed that the SeNPs synthesized by SOLE extract have notable antidiabetic and antioxidant activities, which implies a combination of selenium bioactivity and some other phytochemical compounds in S. officinalis.
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Pretreatment with PEIV significantly mitigated effects of LPS-induced liver injury by regulating biochemical parameters, reducing oxidative stress and inflammation, and preserving liver architecture, suggesting its potential as a natural therapeutic agent for liver diseases.
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