Jul 2026· The Journal of pharmacy· Vol 6, pp. 341-356· 0 citations· 58 references
TL;DR
Electrospun nanofibre membranes loaded with Curcuma xanthorrhiza-loaded nanofibres exhibit promising physical and chemical properties in their formulation, and it is suggested that the loading capacity of the extract be increased.
Abstract
Introduction: Chronic wounds are a major global health concern because their slow healing increases the risk of infection. Conventional dressings often fail to provide both effective antibacterial protection and optimal moisture control. Electrospun nanofibre membranes, with porous structures that resemble the extracellular matrix, offer a promising alternative. Curcuma xanthorrhiza, a traditional Southeast Asian rhizome, is rich in bioactive compounds such as curcumin and xanthorrhizol, which are known for their anti-inflammatory, antioxidant, and antibacterial properties. Methods: In this study, coaxial electrospinning was used to create core–shell nanofibre membranes, featuring polycaprolactone as the core and a gelatine/chitosan blend as the shell. Curcuma extract was incorporated at 1% (w/w) into the core. The resulting fibres were examined for their morphology, chemical composition, and thermal stability using scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. Antibacterial activity was tested against Staphylococcus aureus and Escherichia coli using the disc diffusion method. Results and Discussion: Nanofibres loaded with Curcuma extract were smooth, continuous, and nanoscale in diameter, while fibres without extract were thicker due to a higher polymer concentration. The average fibre diameter ranged from 120.3 to 284.2 nm. Chemical analysis confirmed successful incorporation of the extract, with characteristic functional groups preserved and clear interactions between the polymers and bioactive compounds. Thermal analysis showed the fibres were stable up to 300°C. Antibacterial testing of C. xanthorrhiza-loaded nanofibres demonstrated no activity against S. aureus (0 mm) and E. coli (0 mm). Conclusion: In this study, C. xanthorrhiza-loaded nanofibres exhibit promising physical and chemical properties in their formulation. While the antibacterial activity was limited at the current tested concentration, it is suggested that the loading capacity of the extract be increased.
The findings suggest that nanofiber wound dressings formulated with nanoscale materials represent a promising and effective alternative to conventional wound dressings, particularly for the therapeutic management of injuries associated with chemical, biological, radiological, and nuclear(CBRN) incidents.
N. Tufan, Halis Uğuz, S. Karakurt· Polymer Bulletin· 0 citations
Through rational core-shell design, this study integrates antioxidant and immunomodulatory functions within a single coaxially electrospun scaffold, offering a clinically translatable strategy for chronic diabetic wound repair and the comprehensive structural and functional reconstruction of skin tissue.
Kexin Feng, Xiaoyu Wang, Zichao Cai et al.· Journal of materials chemist...· 0 citations
The treatment of infected bone defects remains a major clinical challenge due to the limitations of conventional systemic antibiotic therapies and the ability of bacteria to form resilient biofilms. In this context, scaffolds capable of delivering local antibacterial activity while supporting tissue regeneration represent a promising alternative. This study reports the fabrication of 3D-printed composite scaffolds composed of alginate, poly(vinyl alcohol) (PVA), and 45S5 bioactive glass, subsequently functionalized with gelatin (GEL) coatings incorporating manuka honey (MH) or oregano essential oil (OEO). Release studies showed that approximately 90% of MH and OEO were released within the first 7 days, suggesting a burst release mechanism. This translated into strong initial antibacterial activity of GEL + MH and GEL + OEO scaffolds against Staphylococcus aureus and Escherichia coli, although the effect decreased after 24 h. Based on the MIC values, OEO showed markedly higher antibacterial potential than MH against both bacterial strains, reinforcing its suitability as a potent natural agent. Cytocompatibility assays revealed that while MH and OEO in pure form displayed some cytotoxicity, their incorporation into the gelatin coating markedly reduced adverse effects, maintaining cell viability above the ISO 10993–5 threshold. These findings indicate that phytotherapeutic-functionalized gelatin coatings can provide effective short-term antibacterial protection without compromising cytocompatibility. Strategies to further optimize release profiles and prolong antibacterial activity are discussed. Overall, the developed scaffolds show strong potential for application in tissue engineering, particularly in infection-prone environments such as bone defect repair, with potential relevance to chronic wound healing applications.
Vivian Inês dos Santos, Meng Li, Sara Benhassan et al.· Journal of Materials Science· 0 citations
Findings demonstrate that Aloe vera-mediated AgNPs can impart antibacterial functionality to electrospun PVA wound dressings, and careful optimization of the AgNPs concentration is essential to achieve an appropriate balance among antibacterial performance, cytocompatibility, and mechanical properties.
In this study, a gelatin- and xanthan-gum-based biomaterial enhanced with barbaloin was developed and evaluated for its potential application in wound healing. The scaffold was designed to leverage the biocompatibility of gelatin, structural stability provided by xanthan gum, and therapeutic properties of barbaloin. Physicochemical characterization was conducted using FTIR, XRD, and SEM. XRD patterns indicated an amorphous structure, favorable for enhanced swelling and controlled drug release, whereas FTIR confirmed effective molecular interactions among the components. SEM imaging revealed a porous and interconnected architecture that is essential for cell migration and nutrient exchange. Swelling and porosity assessments demonstrated the ability of the scaffold to efficiently absorb wound exudates and maintain a moist environment conducive to tissue regeneration. Biocompatibility, evaluated via the MTT assay, showed high fibroblast viability, confirming the non-toxic nature of the material. Furthermore, molecular docking studies revealed strong binding affinities between barbaloin and wound healing-related proteins, suggesting its role in modulating inflammation and promoting tissue repair. Overall, the Gelatin/Xanthan Gum/Barbaloin scaffold exhibited excellent physicochemical characteristics, cytocompatibility, and therapeutic potential, making it a promising candidate for advanced wound dressing applications.
Raam Kumar, Saranya Srinivasan, Ashwathi Vijayalekha et al.· Trends in Biomaterials & Art...· 0 citations
