Aloe vera-mediated silver nanoparticles integrated into electrospun PVA fibers for multifunctional wound dressing applications

Design and biological evaluation of antimicrobial PVA/AgNP/zeolite electrospun nanofiber wound dressings

The findings suggest that nanofiber wound dressings formulated with nanoscale materials represent a promising and effective alternative to conventional wound dressings, particularly for the therapeutic management of injuries associated with chemical, biological, radiological, and nuclear(CBRN) incidents.

Investigating silver- and gold-functionalized electrospun PHBV fibers as dual-action antimicrobial and immunomodulatory biomaterials

Electrospun poly-based fibers functionalized with silver and gold nanoparticles demonstrated an excellent balance of safety, cytocompatibility, and antibacterial performance, making them promising candidates for biomedical applications that require both inflammation control and antimicrobial protection.

Biopolymer-Based Membrane Incorporating Capsaicin-Silver Nanoparticles for Enhanced Antibacterial and Wound Healing Efficacy

A mechanically robust and moisture-retentive hydrocolloid dressing for chronic wound management

Due to their prolonged healing times and susceptibility to infection, chronic wounds pose a significant clinical challenge. In order to improve the treatment of chronic wounds, a silver-curcumin (Ag-Cur) hydrocolloid dressing was developed in this work. integrates nanotechnology with polymer-based wound dressings by using Ag-Curcumin nanoparticles (Ag-Cur NPs) as a nano filler, which were prepared and characterized using various techniques to confirm successful formation of stable silver nanoparticles with the acceptable properties, including surface Plasmon resonance (SPR), zeta potential (ZP), dynamic light scattering (DLS), Poly dispersive index (PDI), and HR-TEM. The results demonstrated the formation of Ag-Cur nanoparticles with a hydrodynamic size of 197.3 ± 0.709 nm and a zeta potential of -27.5 ± 0.603 mV. Morphological analyses via SEM and EDX revealed a porous structure with uniform nanoparticle distribution, while mechanical testing demonstrated superior tensile strength and a swelling ratio of 428.76%, surpassing commercial dressings. The hydrocolloid dressings shown high batch-to-batch reproducibility, and the Ag–Cur nanoparticles demonstrated acceptable long-term stability. Biological evaluations showed significant antimicrobial activity against pathogens such as Staphylococcus aureus, Escherichia coli, and Candida albicans, alongside potent anti-inflammatory effects (82.43% albumin denaturation inhibition at 1000 µg/mL) and substantial antibacterial, bactericidal, and anti-biofilm activity against MRSA, highlighting its promise as a multifunctional wound dressing for infection management and reducing biofilm-related healing delay. The sustained release profile, reaching 80% after 100 h, ensures prolonged therapeutic effects. Finally, with a CC50 of 470.06 ± 23.09 µg/mL, the Ag-Cur hydrocolloid demonstrated moderate cytocompatibility with HSF-1 cells. Additionally, Ag-Cur-HCD succeeds over both Blank-HCD and Ag-HCD in suppressing LPS-induced inflammation and oxidative stress in HSF-1 cells, as seen by the IL-1β, TNF-α, and NO levels. As a result, Ag-Cur-HCD considerably modulates important inflammatory and antioxidant pathways. These results suggest that the Ag-Cur hydrocolloid shows potential for future wound dressing applications. Future studies will focus on evaluating the formulation in models of infected and chronic wounds, as well as long-term safety and comparative efficacy assessments.

Electroresponsive PVA/Cu-BTC@Aloe hydrogel dressing for enhanced antibacterial activity and directional cell migration

The integration of electroresponsive materials, natural bioactive constituents, and electrical stimulation provides a promising multifunctional platform for electrically assisted wound management.

Aloe vera integrated ZnO/SWCNT/Ag nanocomposites for accelerated wound repair and scar reduction

For centuries, natural extracts such as Aloe vera have been used in wound care due to their soothing, anti-inflammatory, and healing properties. However, their clinical efficacy can be limited by instability, low bioavailability, and restricted antimicrobial potency. Nanotechnology offers promising strategies to enhance and complement the therapeutic benefits of herbal extracts. In this study, we investigated the wound-healing potential of Aloe vera gel combined with ZnO/SWCNT/Ag (zinc oxide-single-walled carbon nanotubes-silver nanoparticles) nanocomposite. Forty full-thickness excisional wounds (15 mm) were created on the dorsum of 20 Sprague Dawley rats and divided into four treatment groups: ZnO/SWCNT/Ag alone (1 mg/mL), Aloe vera gel (30 mg/mL), the combination of Aloe vera gel with the NPs, and control (saline 0.9%). Wound areas were tracked at days 0, 3, 10, 15, and 21 using calibrated imaging, and skin samples were harvested for histopathological analysis. The ZnO/SWCNT/Ag nanocomposite alone accelerated wound closure compared to Aloe vera and saline control, while combining Aloe vera with the nanocomposite improved wound healing compared to Aloe vera alone at day 10 (p < 0.05). Although wound closure was similar across all groups by day 21, nanoparticle-treated wounds showed less variability and more uniform healing. Scar area analysis revealed significant reductions for ZnO/SWCNT/Ag based treatment and the combination compared to Aloe vera (p < 0.05), whereas differences versus saline control were not statistically significant. Additionally, the formulations demonstrated strong antibacterial activity against Escherichia coli and enhanced antioxidant properties. These findings suggest that ZnO/SWCNT/Ag nanoparticles may serve as a supportive platform to enhance the wound-healing behaviour of Aloe vera.