Aug 2026· microPublication Biology· Vol 2026· 0 citations· 28 references
Medicine
TL;DR
It is reported that seven transgenic ionotropic glutamate receptor (iGluR) subunit reporter lines are variably expressed in hub cells of the Drosophila testis stem cell niche, suggesting a novel form of inter-organ communication for this tissue.
Abstract
Adult stem cells are required to maintain tissue homeostasis and understanding their regulation is essential to leveraging their utility. Here we report that seven transgenic ionotropic glutamate receptor (iGluR) subunit reporter lines are variably expressed in hub cells of the Drosophila testis stem cell niche, suggesting a novel form of inter-organ communication for this tissue. While HCR-FISH confirms that one of the iGluR subunits, GluRIIA , is transcribed in hub cells, we do not detect GluRIIA protein expression. Furthermore, hub cells are not sensitive to exogenous glutamate and hub-specific knockdown of the essential iGluR subunits does not phenotypically affect cells of the testis apex. Altogether this suggests that iGluRs are not essential for stem cell niche homeostasis.
Adult stem cells are critical for tissue homeostasis. They reside in dynamic, supportive microenvironments termed niches, which are generated by specialized niche cells. The adult Drosophila melanogaster testis contains a single niche generated by a small cluster of quiescent somatic niche cells called hub cells. Altho...
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