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#protein folding

The human papillomavirus L2 protein in the capsid is an ensemble of related structures poised to exit the virus particle

Changin Oh Huaxin Yu Patrick M. Buckley Frank L. Horrigan Kashif Mehmood Jeongjoon Choi Jun Liu Daniel DiMaio
Aug 2026 · bioRxiv · 0 citations
Biology

TL;DR

A structural model of L2 within the capsid is developed using cryo-EM single particle analysis of HPV16 pseudovirus capsids with and without the L2 protein combined with AlphaFold3 predictions and molecular dynamics simulations to develop a structural basis for understanding how L2 is organized in the capsid poised to initiate its action during virus entry.

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