ABSTRACT Spirochetes are evolutionarily distinct bacteria defined by their spiral morphology, unique means of motility, and periplasmic flagella (PFs). Because these flagella reside within the periplasm and are mechanically integrated with the cell body, their assembly must be precisely coordinated with cell growth and...
Kai Zhang, Wang-Biao Guo, Michael J. Lynch et al.· mBio· 0 citations
The bacterial type III secretion system (T3SS) uses a membrane-embedded injectisome assembly to export effector proteins into host cells. While atomic-level structural details have been revealed for much of the T3SS apparatus, the model of the cytoplasmic sorting platform remains largely low-resolution. A central struc...
Sean K. Whittier, Shoichi Tachiyama, Samira Heydari et al.· PLoS Pathogens· 0 citations
In-situ near-atomic structures of the sheathed flagellar motor within intact cells are determined, revealing how the distinctive architecture and dynamics of the sheathed flagellum support V. cholerae motility, environmental survival, and persistent colonization of the human gut.
Wang-Biao Guo, Jian Yue, Jin Hwan Park et al.· Nature Communications· 1 citation
A structural model of L2 within the capsid is developed using cryo-EM single particle analysis of HPV16 pseudovirus capsids with and without the L2 protein combined with AlphaFold3 predictions and molecular dynamics simulations to develop a structural basis for understanding how L2 is organized in the capsid poised to...
Changin Oh, Huaxin Yu, Patrick M. Buckley et al.· bioRxiv· 0 citations
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